TITLE

DEVELOPMENT AND EVALUATION OF THE SINOMENINE TRANSDERMAL PATCH

AUTHOR(S)
Jianping Wang; Jinlan Ruan; Changgong Zhang; Yujie Ye; Yaling Cai; Yunxia Wu
PUB. DATE
October 2008
SOURCE
Pakistan Journal of Pharmaceutical Sciences;Oct2008, Vol. 21 Issue 4, p407
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.
ACCESSION #
39342796

 

Related Articles

  • A novel miniaturized extraction capillary for determining gaseous formaldehyde by high-performance liquid chromatography. Ueta, Ikuo; Mochizuki, Suguru; Kawakubo, Susumu; Kuwabara, Tetsuo; Jinno, Kiyokatsu; Saito, Yoshihiro // Analytical & Bioanalytical Chemistry;Jan2015, Vol. 407 Issue 3, p899 

    A novel miniaturized sample extraction capillary was developed to provide a simple and sensitive method for analyzing gaseous formaldehyde (FA) using conventional high-performance liquid chromatography (HPLC). The extraction capillary was prepared by packing silica gel particles in a stainless...

  • FORMULATION AND CHARACTERIZATION OF ASCORBYL PALMITATE LOADED O/W MICROEMULSION. MAULUDIN, RACHMAT; MOHAMAD, SITI FARHANAH B. T.; SUCIATI, TRI // International Journal of Pharmacy & Pharmaceutical Sciences;2014, Vol. 6 Issue 9, p294 

    Objective: Ascorbyl palmitate (AP) is an effective free radical-scavenging antioxidant which promotes skin health and vitality. Besides that, AP helps to enhance the synthesis of collagen. Moreover, AP helps to reduced UVB that can induce erythema (sunburn). However, AP relatively unstable and...

  • A Passive Sampling Study of Small-Scale Variations in Ambient Acetaldehyde and Formaldehyde Concentrations. Evans, Amanda M.; Stuart, Amy L. // Air, Soil & Water Research;2011, Issue 4, p71 

    Radiello passive diffusive aldehyde samplers were used to measure ambient formaldehyde and acetaldehyde levels, approximately every 0.7 km in a 10 km2 sampling area in Hillsborough County, Florida from January 21 to 28, 2010. Samples were analyzed for aldehyde-DNPH derivatives via high...

  • DEVELOPMENT OF TEST METHOD FOR EVALUATION OF FORMALDEHYDE IN TEXTILE AUXILIARIES. Sathianarayanan, M. P.; Vairagi, S. P. // BTRA Scan;Sep2014, Vol. 44 Issue 3, p21 

    The article discusses a study on the development of a test method on chromatography to estimate the formaldehyde content in textile auxiliaries. Topics discussed include standardization of formaldehyde, extraction and analysis by high performance liquid chromatography (HPLC), and formaldehyde...

  • AN ALTERNATIVE METHOD FOR FORMALDEHYDE DETERMINATION IN AQUEOUS SOLUTIONS. Ernes, D. A. // Book of Papers, National Technical Conference of AATCC;1984, p209 

    The determination of formaldehyde release from fabrics is typically done utilizing the AATOC Test Method #112-1982. This method consists of an extraction step followed by analysis using one of two spectrophotometric techniques. An alternative method for the analysis of the extracts is described...

  • Determination of formaldehyde in squid by high-performance liquid chromatography. Jiangrong Li; Junli Zhu; Lifang Ye // Asia Pacific Journal of Clinical Nutrition;2007 Supplement 1, Vol. 16, p127 

    Great attention has been paid to volatile toxic aldehydes like formaldehyde in aquatic products. In order to investigate content of formaldehyde in squid and squid products, a high-performance liquid chromatography (HPLC) method was developed for determination of formaldehyde. Based on steam...

  • HPLC and Anti-Inflammatory Studies of the Flavonoid Rich Chloroform Extract Fraction of Orthosiphon Stamineus Leaves. Mun Fei Yam; Vuanghao Lim; Salman, Ibrahim Muhammad; Ameer, Omar Ziad; Lee Fung Ang; Rosidah, Noersal; Abdulkarim, Muthanna Fawzy; Abdullah, Ghassan Zuhair; Rusliza Basir; Amirin Sadikun; Mohd Zaini Asmawi // Molecules;Jun2010, Vol. 15 Issue 6, p4452 

    The aim of the present study was to verify the anti-inflammatory activity of Orthosiphon stamineus leaf extracts and to identify the active compound(s) contributing to its anti-inflammatory activity using a developed HPLC method. Active chloroform extract of O. stamineus was fractionated into...

  • Correlation between Stated and Measured Concentrations of Acrylate and Methacrylate Allergens in Patch-Test Preparations. Goon, Anthony Teik-Jin; Bruze, Magnus; Zimerson, Erik; Sörensen, Östen; Chee-Leok Goh; David Soo-Quee Koh; Isaksson, Marléne // Dermatitis (Decker Publishing);Jan/Feb2011, Vol. 22 Issue 1, p27 

    Background: Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations. Objective: To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments...

  • Development of non-invasive transdermal patch of Emblica officinalis for anti atherosclerotic activity. Jasuja, Nakuleshwar Dut; Sharma, Parduman Raj; Sharma, Sunita; Joshi, Suresh C. // International Journal of Drug Delivery;2013, Vol. 5 Issue 4, p402 

    The present study was designed to formulate matrix type transdermal patches of a potent anti atherosclerotic botanical Emblica officinalis on a mercury substrate and evaluated for physicochemical parameters like thickness, % flatness, weight variation, moisture uptake, moisture content, folding...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics