2008 - Review: Statins are effective for prevention of cardiovascular events in patients without coronary heart disease

McAlister, Finlay A.
April 2009
ACP Journal Club;4/21/2009, Vol. 150 Issue 4, p3
Academic Journal
The article discusses whether statins are effective for primary prevention of cardiovascular (CV) events. Medical studies comparing statins with placebo, standard therapy, or no treatment for primary prevention were taken into account. Meta-analysis showed that statins reduces all-cause mortality, CV mortality, all MI, fatal myocardial infarction (MI), stroke, and major risk factors associated with the disease in comparison with placebo


Related Articles

  • Serum lipoprotein levels in takotsubo cardiomyopathy vs. myocardial infarction. Gaddam, Sainath; Nimmagadda, Krishna C.; Nagrani, Tarun; Naqi, Muniba; Wetz, Robert V.; Weiserbs, Kera F.; McCord, Donald; Ghavami, Foad; Gala, Bhavesh; Lafferty, James C. // International Archives of Medicine;2011, Vol. 4 Issue 1, p14 

    Background: In the setting of myocardial infarction (MI) or acute coronary syndrome (ACS), current guidelines recommend early and aggressive lipid lowering therapy with statins, irrespective of the baseline lipoprotein levels. Takotsubo cardiomyopathy (TCM) patients have a clinical presentation...

  • Review: Statins reduce mortality and cardiovascular events in adults at risk for cardiovascular disease. Davidson, Richard A.; Rosenberg, Eric; Brugts, J. J. // ACP Journal Club;10/20/2009, Vol. 151 Issue 4, p11 

    The article discusses a study conducted to examine if statins reduce mortality in adults without established cardiovascular disease (CVD) but with CVD risk factors. The results indicated positivity in statins reducing mortality and cardiovascular events. Later it was also found that the...

  • A Rationale for Combined Therapy with a Calcium Channel Blocker and a Statin: Evaluation of Basic and Clinical Evidence. Mason, R. Preston // Current Drug Targets - Cardiovascular & Haematological Disorders;Dec2005, Vol. 5 Issue 6, p489 

    Calcium channel blockers and HMG-CoA reductase inhibitors are widely used for the management of hypertension and dyslipidemia, respectively. The use of these agents in the prevention and treatment of cardiovascular disease remains largely based on their actions in lowering blood pressure and...

  • The Miracle of Niacin. Agatston, Arthur // Prevention;May2009, Vol. 61 Issue 5, p34 

    The article discusses a University of Washington study that shows the benefits of high doses of niacin when taken with statin drugs in lowering the risk factors for heart attack. When taken with statin drugs, niacin raises HDL cholesterol and lowers triglycerides, enlarges the smallest particles...

  • Results from the ACCORD Lipid Study.  // MD Conference Express;May2010, p11 

    The article discusses the results of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid Study, which was presented in the American College of Cardiology (ACC) 59th Annual Scientific Session. It says that the ACCORD Lipid Study does not encourage the use of combined statin and...

  • Efficacy of Standard and Intensive Statin Treatment for the Secondary Prevention of Cardiovascular and Cerebrovascular Events in Diabetes Patients: A Meta-Analysis. de Vries, Folgerdiena M.; Kolthof, Johan; Postma, Maarten J.; Denig, Petra; Hak, Eelko // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Aims: To estimate the efficacy of standard and intensive statin treatment in the secondary prevention of major cardiovascular and cerebrovascular events in diabetes patients. Methods: A systematic search was conducted in Medline over the years 1990 to September 2013. Randomized, double-blind,...

  • Dr Foster's case notes.  // BMJ: British Medical Journal (International Edition);9/18/2004, Vol. 329 Issue 7467, p645 

    Examines the relationship between the prescribing of lipid regulating drugs or statins to the number of admissions for myocardial infarction in England. Conduct of the study; Finding that the large increase in the cost and volume of the prescribing of lipid regulating drugs has been associated...

  • Early initiation of statins following ACS does not improve outcomes.  // Journal of Family Practice;Aug2006, Vol. 55 Issue 8, p664 

    The article presents a study on whether early initiation of statins following the onset of acute coronary syndromes (ACS) will reduce the short-term risk of death, recurrent myocardial infarction or stroke. The study was carried out through meta-analysis of randomized controlled trials. The...

  • Guidelines: New Lows for LDL Target Levels. Mitka, Mike // JAMA: Journal of the American Medical Association;8/25/2004, Vol. 292 Issue 8, p911 

    Reports on an update of key cholesterol level guidelines. How the new guidelines further reduce the safe level of LDL-C or bad cholesterol for all patients; Determination of the National Cholesterol Education Program that patients at risk for heart attacks need to lower their LDL further than...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics