Karaciğer ve böbrek üzerine etanolün toksisitesi ve L-NAME' in koruyucu etkisi

Kutlubay, Recep; Oğuz, Emin Oğuzhan; Turgut, Günfer; Kocamaz, Erdoğan
December 2008
Medical Journal of Suleyman Demirel University;Dec2008, Vol. 15 Issue 4, p11
Academic Journal
Aim: To show the histological liver and renal damage caused by ethanol at a certain dose and to show possible protective role of L-NAME. Materials and Methods: In this study, 40, 6 month-old Wistar rats were randomly divided into four groups: I- Control (n=10) II- Etanol (n=10) III-L-NAME (n=10) IV-Etanhol + L-NAME (n=10) 1g/lt L-NAME and 20% etanol were added into drinking water for 30 days. Results: At the end of the experiment, no animal died to due the given agents. In kidney, in ethanol group, narrowing in Bowman spaces, vacuolisation and pathologic appearance in tubule epithelium were observed. Ethanol + L-NAME group showed normal Bowman spaces similar in control group and almost normal tubuli structure. Only L-NAME group showed normal appearance as it was in control group in terms of glomerular and tubular structures.In liver, in ethanol group there was significant narrowing in sinusoids, in some places irregular hepatocyte accumulations, degenrative hepatocytes and lack of sinusoids. In ethanol + L-NAME group sinusoids had normal appearance. In the perifery of some lobules, altough there were slight irregularities, hepatocyte colons were normal. Only L-NAME group showed no pathology as it was in control group. Conclusion: According to the findings L-NAME ameliorates the histological damage in liver and kidney caused by etanol.


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