Silencing of Heat Shock Protein 70 Expression Enhances Radiotherapy Efficacy and Inhibits Cell Invasion in Endometrial Cancer Cell Line

April 2009
Croatian Medical Journal;Apr2009, Vol. 50 Issue 2, p143
Academic Journal
No abstract available.


Related Articles

  • Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells. Sekihara, Kazumasa; Harashima, Nanae; Tongu, Miki; Tamaki, Yukihisa; Uchida, Nobue; Inomata, Taisuke; Harada, Mamoru // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Hyperthermia (HT) improves the efficacy of anti-cancer radiotherapy and chemotherapy. However, HT also inevitably evokes stress responses and increases the expression of heat-shock proteins (HSPs) in cancer cells. Among the HSPs, HSP70 is known as a pro-survival protein. In this study, we...

  • Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin. Wu, X.; Wanders, A.; Wardega, P.; Tinge, B.; Gedda, L.; Bergstrom, S.; Sooman, L.; Gullbo, J.; Bergqvist, M.; Hesselius, P.; Lennartsson, J.; Ekman, S. // British Journal of Cancer;1/27/2009, Vol. 100 Issue 2, p334 

    Heat shock protein 90 (Hsp90) has been demonstrated to protect oncogenic variants of signalling molecules from degradation and may consequently serve as a therapeutic target for the treatment of oesophageal cancer for which adequate therapy is often lacking. We studied the expression of Hsp90 in...

  • Studies on the role of osteopontin-1 in endometrial cancer cell lines. Hahne, J.C.; Meyer, S.R.; Kranke, P.; Dietl, J.; Guckenberger, M.; Polat, B.; Hönig, A. // Strahlentherapie und Onkologie;Dec2013, Vol. 189 Issue 12, p1040 

    Background: Osteopontin-1 is a well characterized protein in many tumour entities. Multiple roles in the processes invasion, metastasis and angiogenesis of tumours are attributed to osteopontin-1. The putative role of osteopontin-1 has not been characterized for endometrial cancer. Material and...

  • Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer. De Bacco, Francesca; Luraghi, Paolo; Medico, Enzo; Reato, Gigliola; Girolami, Flavia; Perera, Timothy; Gabriele, Pietro; Comoglio, Paolo M.; Boccaccio, Carla // JNCI: Journal of the National Cancer Institute;Apr2011, Vol. 103 Issue 8, p645 

    Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause disease relapse with metastatic progression. The MET oncogene encodes the hepatocyte growth factor (HGF) receptor and is known to drive...

  • Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy. Wang, R. E. // Current Medicinal Chemistry;Sep2011, Vol. 18 Issue 27, p4250 

    Recent progresses in cancer therapy suggest the importance of targeting more than one protein targets or signaling pathways. In events of stresses including the therapeutic treatments, damaged proteins are either repaired by heat shock proteins or ubiquitin-tagged for proteasome-dependent...

  • Knockdown of Slug inhibits migration and invasion of pancreatic cancer cells. MENG Xian-kui; ZHANG Lei // Journal of Xi'an Jiaotong University (Medical Sciences);Jan2014, Vol. 35 Issue 1, p69 

    Objective To investigate the effect of transcription factor Slug on migration and invasion capacity in pancreatic cancer so as to shed new light on the development of target therapy for pancreatic cancer. Methods The relevant siRNA was used to silence the expression of Slug of pancreatic cancer...

  • Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells. Fukuoka, Masashi; Yoshida, Mariko; Eda, Akiko; Takahashi, Masaki; Hohjoh, Hirohiko // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Heat shock, sudden change in temperature, triggers various responses in cells for protecting the cells from such a severe circumstance. Here we investigated gene silencing mediated by endogenous microRNAs (miRNAs) in mammalian cells exposed to a mild hyperthermia, by means of miRNA activity...

  • Functional proteomic screens reveal an essential extracellular role for hsp90a in cancer cell invasiveness. Eustace, Brenda K.; Sakurai, Takashi; Stewart, Jean K.; Yimlamai, Dean; Unger, Christine; Zehetmeier, Carol; Lain, Blanca; Torella, Claudia; Henning, Stefan W.; Beste, Gerald; Scroggins, Bradley T.; Neckers, Len; Ilag, Leodevico L.; Jay, Daniel G. // Nature Cell Biology;Jun2004, Vol. 6 Issue 6, p507 

    Tumour cell invasiveness is crucial for cancer metastasis and is not yet understood. Here we describe two functional screens for proteins required for the invasion of fibrosarcoma cells that identified the molecular chaperone heat shock protein 90 (hsp90). The hsp90a isoform, but not...

  • NSSR1 is regulated by testosterone in the mouse uterus and extensively expressed in endometrial carcinoma. Peng, Zheng-Yu; Xiao, Ping-Jie; Qi, Yao; Zhang, Wei; Chen, Xian-Hua; Xu, Ping // Tumor Biology;2011, Vol. 32 Issue 2, p359 

    Neural salient serine/arginine-rich protein 1 (NSSR1) has been found to play important roles in inhibiting alternative splicing during heat shock and mitosis and is predominantly expressed in neural tissues such as cerebral neurons, cerebellar Purkinje cells and bipolar cells of the retina....

  • shRNA-Mediated XRCC2 Gene Knockdown Efficiently Sensitizes Colon Tumor Cells to X-ray Irradiation in Vitro and in Vivo. Qin Wang; Yan Wang; Liqing Du; Chang Xu; Yuanming Sun; Bing Yang; Zhijuan Sun; Yue Fu; Lu Cai; Saijun Fan; Feiyue Fan; Qiang Liu // International Journal of Molecular Sciences;Feb2014, Vol. 15 Issue 2, p2157 

    Colon cancer is one of the most common tumors of the digestive tract. Resistance to ionizing radiation (IR) decreased therapeutic efficiency in these patients' radiotherapy. XRCC2 is the key protein of DNA homologous recombination repair, and its high expression is associated with enhanced...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics