Primary Gastrointestinal Sarcomas

Medina-Franco, Heriberto; Urist, Marshall M.; Heslin, Martin J.; Eltoum, Isam E.
December 2000
American Surgeon;Dec2000, Vol. 66 Issue 12, p1171
Academic Journal
Gastrointestinal (GI) sarcomas are uncommon tumors with the majority of previous studies performed over long time intervals. The purpose of this review is to analyze our single-institution experience with primary GI sarcomas. Between January 1990 and June 1998, 27 adult patients with primary GI sarcomas were identified in the tumor registry at the University Hospital, School of Medicine of University of Alabama at Birmingham and retrospectively reviewed. Patient, tumor, and treatment factors as well as expression of p53 and Ki-67 were analyzed with overall survival as the main outcome variable. Statistical analysis was performed by log rank test and Cox regression. Significance was defined as P < 0.05. Median age was 55 years (range 36-80 years). The stomach was the most common site of presentation (59%) followed by small bowel (29%). The average tumor size was 15 cm (range 2-46 cm). A complete resection was performed in 22 patients (81.5%). Fifteen tumors were classified as low grade (55.5%). Actuarial 3-year survival was 43 percent with a median follow-up of 16 months. Overexpression of p53 and Ki-67 correlated with a trend to decreased survival but it did not reach statistical significance. Multivariate analysis found incomplete resection (P = 0.00001) and high grade (P = 0.003) to be significant negative prognostic factors. We conclude that GI sarcomas tend to be large tumors with most arising in the stomach and proximal GI tract. Complete surgical resection is associated with prolonged survival and despite the large size of these tumors should be attempted whenever possible.


Related Articles

  • Primary Gastrointestinal Kaposi's Sarcoma in a Patient with Acquired Immune Deficiency Syndrome. Lustbader, Ian; Sherman, Alex // American Journal of Gastroenterology;Sep1987, Vol. 82 Issue 9, p894 

    Gastrointestinal involvement by Kaposi's sarcoma in patients with cutaneous or lymph node involvement is common. Since the advent of the acquired immune deficiency syndrome in 1981, primary gastrointestinal involvement, i.e., without skin or lymph node involvement, has not been...

  • Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers. Lee, Su Jin; Hong, Jung Yong; Kim, Kyung; Kim, Kyoung-Mee; Kang, So Young; Lee, Taeyang; Kim, Seung Tae; Park, Se Hoon; Park, Young Suk; Lim, Ho Yeong; Kang, Won Ki; Lee, Jeeyun; Park, Joon Oh // Journal of Oncology;1/22/2020, p1 

    Successful identification and targeting of oncogenic gene fusion is a major breakthrough in cancer treatment. Here, we investigate the therapeutic implications and feasibility of using a targeted RNA sequencing panel to identify fusion genes in gastrointestinal and rare cancers. From February...

  • Gastrointestinal carcinoma antigen GA733: target for immunodestruction and potential modifier of invasiveness and chemoresponsiveness. Zutter, Mary M.; Zutter, M M // JNCI: Journal of the National Cancer Institute;05/06/98, Vol. 90 Issue 9, p642 

    Editorial. Presents information on gastrointestinal carcinoma antigen GA733. Comparison of the effect of re-expressing either the human antigen GA733 or its murine homologue, in the mEGP-negative colorectal carcinoma cells line CT-26; Description of cell-cell adhesion molecule; Reference to...

  • Summaries for Patients. Increased Risk for Gastrointestinal Cancer in Childhood Cancer Survivors.  // Annals of Internal Medicine;6/5/2012, Vol. 156 Issue 11, pI-36 

    The article presents questions and answers related to gastrointestinal cancer including reasons for the gastrointestinal study by the researchers, limitations of the study and the implications of the study.

  • Management of carcinomas of the upper gastrointestinal tract. Ellis, Paul; Cunningham, David // BMJ: British Medical Journal (International Edition);3/26/94, Vol. 308 Issue 6932, p834 

    Examines the management of carcinomas of the upper gastrointestinal tract. Figures of the surgery as option for treating gastrointestinal system cancer; Improvements in understanding the biology of the tumors; Advancement in the palliative management of the tumors.

  • The emerging role of caspase inhibitors in gastrointestinal cancers. Shiraki, Katsuya; Takase, Koujiro; Nakano, Takeshi // Journal of Gastroenterology;2002, Vol. 37 Issue 5, p323 

    Apoptosis is an important process in a wide variety of biological systems, and dysregulation of apoptosis is implicated in many human diseases, including malignancy. In fact, cancer cells demonstrate resistance to a variety of apoptotic stimuli, so that an understanding of the inhibitory...

  • Production and characterisation of a recombinant scFc reactive with human gastrointestinal carcinomas. Kim, D.-J.; Chung, J.-H.; Ryu, Y.-S.; Rhim, J.-H.; Kim, C.-W.; Suh, Y.; Chung, H.-K. // British Journal of Cancer;8/12/2002, Vol. 87 Issue 4, p405 

    SC142-reactive antigen are highly glycosylated glycoproteins expressed on tissues of gastric and colon cancers but not on normal tissues, Murine SC142 antibody specific for the SC142-reactive antigen has been produced by immunisation with SNU16 stomach cancer cells. However, SC142 antibody has...

  • The Gastrointestinal Lesions and Complications of the Leukemias. Prolia, J.C.; Kirsner, Joseph B. // Annals of Internal Medicine;Dec64, Vol. 61 Issue 6, p1084 

    Studies the occurrence of gastrointestinal lesions in the course of leukemia. Types of leukemia; Age and sex distribution of leukemia; Type of esophageal lesions in patients with leukemia; Types of gastric lesions in patients with leukemia; Principal lesions in the small intestines; Type of...

  • Gastroesophageal cancer incidence, survival similar regardless of location. Southall, Jennifer; Taliercio, Adam; Volansky, Rob // Hem/Onc Today;11/25/2013, Vol. 14 Issue 22, p24 

    The article reports on a study by Z. Wang et al and published in a 2013 issue of "Cancer," which found that rural area residents were not significantly more likely to develop or die of gastroesophageal cancer than metropolitan area residents.

  • Bisphosphonates and gastrointestinal cancers: negative study.  // Africa Health;Jul2013, Vol. 35 Issue 5, p45 

    The article discusses the study "Exposure to Bisphosphonates and Risk of Gastrointestinal Cancer: Series of Nested Case-Control Studies With QResearch and CPRD Data," conducted by researcher Y. Vinogradova and colleagues.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics