TITLE

Determination of 2-ethylhexyl 4-(dimethylamino) benzoate using membrane-assisted liquid–liquid extraction and gas chromatography-mass spectrometric detection

AUTHOR(S)
March, J. G.; Genestar, C.; Simonet, B. M.
PUB. DATE
June 2009
SOURCE
Analytical & Bioanalytical Chemistry;Jun2009, Vol. 394 Issue 3, p883
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A flow-cell for micro-porous membrane liquid–liquid extraction with a sheet membrane was used to extract 2-ethylhexyl 4-(dimethylamino) benzoate (EDB) from urine of solar-cream users and spiked wine samples. The cell enabled the target analyte to be extracted from 7.9 mL of donor solution into 200 μL of acceptor solution (decane). After extraction, the acceptor solution was transferred to a micro-vial for GC-MS analysis without derivation. In this work, variables affecting the enrichment factor were also studied, such as organic solvent, extraction time, recirculation flow of the donor solution through the donor chamber, presence of potassium chloride and ethanol in the donor solution and pH. The method has been evaluated in terms of linearity, sensitivity, precision, limits of detection and quantification and extraction efficiency. Limits of quantification were 1 and 3 μg L−1 EDB for urine and wine, respectively. Quantitative analysis has been carried out by applying the method of standard additions. Within- and between-day relative standard deviations were lower than 12% and 20%, respectively. EDB was found in the urine of users of cream containing EDB in the concentration interval 1.2–7.2 μg L−1. Therefore, this provides evidence of EDB dermal absorption and subsequent excretion through the urinary tract. EDB was not found in the analysed wine samples.
ACCESSION #
38798687

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics