Advancing drug therapy of the metabolic syndrome

Grundy, Scott M
May 2009
Nature Reviews Drug Discovery;May2009, Vol. 8 Issue 5, p341
Academic Journal
The metabolic syndrome — a group of factors that raise the risk of cardiovascular disease and type 2 diabetes — is increasingly common. How might the challenges of developing improved therapies to normalize these risk factors be approached?


Related Articles

  • Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations. Perez-Martinez, Pablo; Perez-Caballero, Ana I.; Garcia-Rios, Antonio; Yubero-Serrano, Elena M.; Camargo, Antonio; Gomez-Luna, Maria J.; Marin, Carmen; Gomez-Luna, Purificacion; Dembinska-Kiec, Aldona; Rodriguez-Cantalejo, Fernando; Tinahones, Francisco J.; Roche, Helen M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose; Delgado-Lista, Javier; Clarke, Robert // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism....

  • Management of Type 2 Diabetes Mellitus and Cardiovascular Risk: Lessons from Intervention Trials. Yki-Järvinen, H. // Drugs;Nov2000, Vol. 60 Issue 5, p975 

    Although the diagnosis of type 2 (noninsulin-dependent) diabetes mellitus is made when blood glucose levels exceed values which increase the risk of microvascular complications, macrovascular disease is the major complication of type 2 diabetes mellitus. Both epidemiological and prospective data...

  • The CAPN10 Gene Is Associated with Insulin Resistance Phenotypes in the Spanish Population. Sáez, María E.; González-Sánchez, José L.; Ramírez-Lorca, Reposo; Martínez-Larrad, María T.; Zabena, Carina; González, Alejandro; Morón, Francisco J.; Ruiz, Agustín; Serrano-Ríos, Manuel // PLoS ONE;2008, Vol. 3 Issue 8, p1 

    Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been...

  • Shorts. Klotter, Jule // Townsend Letter;May2007, Issue 286, p26 

    The article offers news briefs related to medicine in the U.S. Family doctors who care for 90% of the nation's diabetics are experiencing a difficult adjustment on medications and monitoring patients with several diseases. Metabolic syndrome is labeled for a group of measurements associated with...

  • Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease.  // Cardiovascular Diabetology;2011, Vol. 10 Issue 1, p80 

    The article informs on a research that analyzes the effect of type two 2 diabetes and metabolic syndrome on myocardial structure and microvasculature of patients with coronary artery disease. It is mentioned that type two diabetes and metabolic syndrome are often the causative factors for...

  • Stability of the factorial structure of metabolic syndrome from childhood to adolescence: a 6- year follow-up study.  // Cardiovascular Diabetology;2011, Vol. 10 Issue 1, p81 

    The article offers information on a research conducted by the authors that analyzes the stability of factorial structure of metabolic syndrome form childhood to adolescence. It is mentioned that metabolic syndrome is a combination of various cardiometabolic risk factors that predicts...

  • Abdominal Obesity Determines the Cardiovascular Risk in Type 2 DM: A Cross-Sectional Study in Spain. Albarran, Olga Gonzalez; Lahera, Marcos; Segura, Julian; Ruilope, Luis M.; Aragón, Carmen; Segura, Raúl; Sancho, José M. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA595 

    Obesity and Metabolic syndrome (MS) have been associated with a high incidence of cardiovascular events. The aims of the present work were 1) to evaluate the prevalence of abdominal obesity (AO) and MS in a cohort of patients with type 2 DM. 2) to assess blood pressure (BP) control rates in...

  • Cardiovascular risk in type 1 diabetes mellitus. Ines Ben Hadj Slama Slim // Indian Journal of Endocrinology & Metabolism;2013 Supplement, Vol. 17 Issue S1, pS7 

    Commonly cardiovascular risk (CVR) is linked to type 2 diabetes mellitus as this type is known to be part of the metabolic syndrome, which includes other cardiovascular factors such as hypertension, dyslipidemia. Inversely, CVR of type 1 diabetes mellitus (T1 DM) is currently being debated apart...

  • Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort.  // American Journal of Clinical Nutrition;Dec2009, Vol. 90 Issue 6, p1608 

    The article presents a study that examines the association between the Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort among nondiabetic Americans. It notes the failure to investigate the benefit of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics