TITLE

Chronic Renal Failure Secondary to Paroxismal Nocturnal Hemoglobinuria

AUTHOR(S)
Varol, Umut; Payzin, Bahriye; Sonbahar, Mehmet; Yaprak, Mustafa
PUB. DATE
September 2008
SOURCE
International Journal of Hematology & Oncology / UHOD: Uluslarar;Sep2008, Vol. 18 Issue 3, p175
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired stem cell disease which is characterized with chronic intravasculer hemolysis and diffuse venous thrombosis. In PNH, renal failure is rare and acute renal failure, which is caused by hemolytic attacks that are usually trigerred by infection and surgical intervention, may happen. A 48-years old male patient who had chronic renal failure (CRF) and has been hemodialysing for about 11 years was admitted to our hospital with the symptoms of pancytopenia. Although Ham's test and sugar water test of our patient were negative, with the results of bone marrow aspiration-biopsy, abdominal MRI and flow cytometry tests, we found out that pancytopenia was due to PNH with type II cells dominancy and CRF was due to hemosiderosis.
ACCESSION #
38590928

 

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