Evotec's MAO-B Inhibitor Fails in Phase II Trial

April 2009
Bioworld Week;4/20/2009, Vol. 17 Issue 16, p4
The article reports on the result of the Phase II clinical trial of smoking cessation drug called EVT 302 that failed to show improvement in the quit rate of smokers, and reassesses the manufacturer Evotec AG plans to reassess the drug following further analysis. EVT 302, a monoamine oxidase B inhibitor, failed to show any significant benefit when combined with a nicotine replacement patch compared to nicotine replacement therapy alone.


Related Articles

  • BUPROPION FOR SMOKING CESSATION. Jackson, Eric A. // Journal of Family Practice;Feb1998, Vol. 46 Issue 2, p111 

    The article discusses research being done on the use of bupropion and placebo for smoking cessation, with reference to a study by R. D. Hurt, D. P. L. Sachs, E. D. Glover et al, which appeared in the 1997 issue of the "New England Journal of Medicine." The randomized, double-blind study...

  • Abstinence from smoking eight years after participation in randomised controlled trial of nicotine patch. Yudkin, Patricia; Hey, Kate; Murphy, Michael; Roberts, Sarah; Welch, Sarah; Walton, Robert // BMJ: British Medical Journal (International Edition);7/5/2003, Vol. 327 Issue 7405, p28 

    Discusses abstinence from smoking eight years after participation in randomised controlled trial of the nicotine patch. Lack of studies that investigate abstinence beyond three years; Participants, methods, results; Lack of effectiveness of the patch; Need for more effective ways to help people...

  • Intensive cessation programme reduces mortality in smokers with heart disease.  // BMJ: British Medical Journal (International Edition);3/24/2007, Vol. 334 Issue 7594, p628 

    The article reports on a study of an intensive smoking cessation program and its potential to reduce death rates among smokers with heart disease. Daily smokers receiving treatment in the hospital for acute heart conditions related to their heart disease are considered high-risk smokers and this...

  • Comparative effectiveness trial of family-supported smoking cessation intervention versus standard telephone counseling for chronically ill veterans using proactive recruitment. Bastian, Lori A.; Fish, Laura J.; Gierisch, Jennifer M.; Rohrer, Lesley D.; Stechuchak, Karen M.; Grambow, Steven C. // Comparative Effectiveness Research;2012 Part 2, Vol. 2, p45 

    Objectives: Smoking cessation among patients with chronic medical illnesses substantially decreases morbidity and mortality. Chronically ill veteran smokers may benefit from interventions that assist them in harnessing social support from family and friends. Methods: We proactively recruited...

  • Bupropion and telephone support helps smokers quit.  // BMJ: British Medical Journal (International Edition);2/21/2004, Vol. 328 Issue 7437, p414 

    Presents a trial based on the question if a combination of bupropion and telephone support aids smokers wanting to quit. Randomised controlled trial in which the combination was measured; How the trial was conducted; Bottom line which is that patients wanting to quit will have a good chance on...

  • Is nicotine replacement therapy for smoking cessation effective in the "real world"? Findings from a prospective multinational cohort study. West, Robert; Xiaolei Zhou // Thorax;Nov2007, Vol. 62 Issue 11, p998 

    Background: Increasing smoking cessation rates is an important goal in preventing lung cancer and chronic obstructive pulmonary disease. Nicotine replacement therapy (NRT) has been found in clinical trials to improve the chances of success at stopping, but recent cross-sectional survey data have...

  • Menstrual Phase Effects on Smoking Cessation: A Pilot Feasibility Study. Carpenter, Matthew J.; Saladin, Michael E.; Leinbach, Ashley S.; Larowe, Steven D.; Upadhyaya, Himanshu P. // Journal of Women's Health (15409996);Mar2008, Vol. 17 Issue 2, p293 

    Background and Objectives: A growing body of research suggests that nicotine withdrawal and cigarette craving may vary across the menstrual cycle and that the luteal phase of the cycle may be associated with increases in each. This potential relationship suggests that careful timing of quit...

  • Cholecystokinin C-45T polymorphism and smoking cessation in women. Ton, Thanh G.; Rossing, Mary Anne; Bowen, Deborah J.; Wilkerson, Hui-Wen; Farin, Federico M. // Nicotine & Tobacco Research;Jan2007, Vol. 9 Issue 1, p147 

    In view of the effect of cholecystokinin (CCK) on dopaminergic neurons in the mesolimbic “reward” pathway of the brain, its gene has been a focus in studies of dopamine-related conditions and behaviors, including smoking. We assessed the association between the CCK C-45T polymorphism...

  • Menthol cigarettes and health risks in Lung Health Study data. Murray, Robert P.; Connett, John E.; Skeans, Melissa A.; Tashkin, Donald P. // Nicotine & Tobacco Research;Jan2007, Vol. 9 Issue 1, p101 

    Whether menthol cigarettes confer a higher risk of death than plain cigarettes is not known. The Lung Health Study (LHS) enrolled 5,887 adult smokers in a clinical trial of smoking cessation and ipratropium in the prevention of chronic obstructive pulmonary disease. LHS participants have been...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics