TITLE

Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases

AUTHOR(S)
Martínez, Alfonso; Santiago, Jose Luis; Varadé, Jezabel; Márquez, Ana; Lamas, José Ramón; Mendoza, Juan Luis; de la Calle, Hermenegildo; Díaz-Rubio, Manuel; de la Concha, Emilio G.; Fernández-Gutiérrez, Benjamín; Urcelay, Elena
PUB. DATE
January 2008
SOURCE
BMC Genomics;2008, Vol. 9, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Selenoprotein S (SelS) protects the functional integrity of the endoplasmic reticulum against the deleterious effects of metabolic stress. SEPS1/SelS polymorphisms have been involved in the increased release of pro-inflammatory cytokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6 in macrophages. We aimed at investigating the role of the SEPS1 variants previously associated with higher plasma levels of these cytokines and of the SEPS1 haplotypes in the susceptibility to develop immune-mediated diseases characterized by an inflammatory component. Results: Six polymorphisms distributed through the SEPS1 gene (rs11327127, rs28665122, rs4965814, rs12917258, rs4965373 and rs2101171) were genotyped in more than two thousand patients suffering from type 1 diabetes, rheumatoid arthritis or inflammatory bowel diseases and 550 healthy controls included in the case-control study. Conclusion: Lack of association of SEPS1 polymorphisms or haplotypes precludes a major role of this gene increasing predisposition to these inflammatory diseases.
ACCESSION #
38122919

 

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