TITLE

Evolution and potential function of fibrinogen-like domains across twelve Drosophila species

AUTHOR(S)
Middha, Sumit; Xinguo Wang
PUB. DATE
January 2008
SOURCE
BMC Genomics;2008, Vol. 9, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The fibrinogen-like (FBG) domain consists of approximately 200 amino acid residues, which has high sequence similarity to the C-terminal halves of fibrinogen β and γ chains. Fibrinogen-related proteins (FREPs) containing one or more FBG domains are found universally in vertebrates and invertebrates. In invertebrates, FREPs are involved in immune responses and other aspects of physiology. To understand the complexity of this gene family in Drosophila, we analyzed FREPs in twelve Drosophila species. Results: Using the genome data from 12 Drosophila species, we identified FBG domains in each species. The results show that the gene numbers in each species vary from 14 genes up to 43 genes. Using sequence profile analysis, we found that FBG domains have high sequence similarity and are highly conserved throughout. By comparison of structure and sequence conservation, some of the FBG domains in Drosophila melanogaster are predicted to function in recognition of carbohydrates and their derivatives on the surface of microorganisms in innate immunity. Conclusion: Sequence and structural analyses show that FREP family across 12 Drosophila species contains conserved FBG domains. Expansion of the FREP families in Drosophila is mainly accounted by a major expansion of FBG domains.
ACCESSION #
38122843

 

Related Articles

  • Large-Scale Trends in the Evolution of Gene Structures within 11 Animal Genomes. Yandell, Mark; Mungall, Chris J.; Smith, Chris; Prochnik, Simon; Kaminker, Joshua; Hartzell, George; Lewis, Suzanna; Rubin, Gerald M. // PLoS Computational Biology;Mar2006, Vol. 2 Issue 3, pe15 

    We have used the annotations of six animal genomes (Homo sapiens, Mus musculus, Ciona intestinalis, Drosophila melanogaster, Anopheles gambiae, and Caenorhabditis elegans) together with the sequences of five unannotated Drosophila genomes to survey changes in protein sequence and gene structure...

  • GYVYBÄ–S KODO TVARKA. Plečkaitytė, Milda // Problemos / Problems;2008, Vol. 74, p162 

    The article describes the biochemical mechanisms of the cell showing their complex but economic action and purposive activity. The classical example of such sophisticated phenomenon is protein folding. Any deviation from the native structure of a protein results in the development of a disease...

  • Determination of complete nucleotide sequence ofHibiscus latent Singapore virus: Evidence for the presence of an internal poly(A) tract. Srinivasan, K. G.; Min, B. E.; Ryu, K. H.; Adkins, S.; Wong, S. M. // Archives of Virology;Jan2005, Vol. 150 Issue 1, p153 

    We have sequenced the complete genome of a hibiscus-infecting tobamovirus,Hibiscus latent Singapore virus(HLSV). The experimental host range of HLSV is similar to that of another distinct species of hibiscus infecting tobamovirus,Hibiscus latent Fort Pierce virus(HLFPV). The genomic structure of...

  • Improved BLAST searches using longer words for protein seeding. Sergey A. Shiryev; Jason S. Papadopoulos; Alejandro A. Schäffer; Richa Agarwala // Bioinformatics;Nov2007, Vol. 23 Issue 21, p2949 

    Motivation: The blastp and tblastn modules of BLAST are widely used methods for searching protein queries against protein and nucleotide databases, respectively. One heuristic used in BLAST is to consider only database sequences that contain a high-scoring match of length at most 5 to the query....

  • Nucleotide sequence of a Japanese isolate of Squash mosaic virus. Han, S. S.; Yoshida, K.; Karasev, A. V.; Iwanami, T. // Archives of Virology;Feb2002, Vol. 147 Issue 2, p437 

    Summary. The complete nucleotide sequence of the RNA-1 of Squash mosaic virus (SqMV) was determined using a Japanese isolate (Y-SqMV). The sequence consisted of 5865 nucleotides excluding the poly (A) at the 3′ terminus and contained a single long open reading frame with a coding capacity...

  • Mutations Enabling Displacement of Tryptophan by 4-Fluorotryptophan as a Canonical Amino Acid of the Genetic Code. Yu, Allen Chi-Shing; Yim, Aldrin Kay-Yuen; Mat, Wai-Kin; Tong, Amy Hin-Yan; Lok, Si; Xue, Hong; Tsui, Stephen Kwok-Wing; Wong, J. Tze-Fei; Chan, Ting-Fung // Genome Biology & Evolution;Mar2014, Vol. 6 Issue 3, p629 

    The 20 canonical amino acids of the genetic code have been invariant over 3 billion years of biological evolution. Although various aminoacyl-tRNA synthetases can charge their cognate tRNAs with amino acid analogs, there has been no known displacement of any canonical amino acid from the code....

  • Complete nucleotide and amino acid sequences and genetic organization of porcine kobuvirus, a member of a new species in the genus Kobuvirus, family Picornaviridae. Reuter, Gábor; Boldizsár, Ákos; Pankovics, Péter // Archives of Virology;Jan2009, Vol. 154 Issue 1, p101 

    Kobuvirus is a new genus in the family Picornaviridae. Two species are currently known: Aichi virus (human kobuvirus) and Bovine kobuvirus (U-1). In this study, the complete nucleotide and amino acid sequences and genetic organization of porcine kobuvirus (Kobuvirus/swine/S-1-HUN/2007/Hungary,...

  • Predicting the Functional Effect of Amino Acid Substitutions and Indels. Yongwook Choi; Sims, Gregory E.; Murphy, Sean; Miller, Jason R.; Chan, Agnes P. // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being developed to provide computational predictions on the functional effects of sequence variations and narrow down the search of casual variants for disease phenotypes....

  • A fast algorithm for determining the best combination of local alignments to a query sequence. Conant, Gavin C.; Wagner, Andreas // BMC Bioinformatics;2004, Vol. 5, p62 

    Background: Existing sequence alignment algorithms assume that similarities between DNA or amino acid sequences are linearly ordered. That is, stretches of similar nucleotides or amino acids are in the same order in both sequences. Recombination perturbs this order. An algorithm that can...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics