TITLE

Disrupted intrinsic functional connectivity in the vegetative state

AUTHOR(S)
Cauda, F.; Micon, B. M.; Sacco, K.; Duca, S.; D'Agata, F.; Geminiani, G.; Canavero, S.
PUB. DATE
April 2009
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Apr2009, Vol. 80 Issue 4, p429
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
It is debatable as to whether the spontaneous blood-oxygen-level dependent fluctuations that are observed in the resting brain in turn reflect consciously directed mental activity or, alternatively, constitute an intrinsic property of functional brain organisation persisting in the absence of consciousness. This report shows for the first time, in three patients, that the persistent vegetative state (PVS) is marked by a dysfunctional default mode network, with decreased connectivity in several brain regions, including the dorsolateral prefrontal cortex and anterior cingulated cortex, especially in the right hemisphere. This finding supports the view that the resting state is involved in self-consciousness, and that the right-hemisphere default state may play a major role in conscious processes. It is speculated that the default state may act as a surrogate marker of PVS with awareness contents and, therefore, could replace a more complex activation paradigm.
ACCESSION #
38021537

 

Related Articles

  • Consciousness, Coma, and Brain Death--2009. Rosenberg, Roger N. // JAMA: Journal of the American Medical Association;3/18/2009, Vol. 301 Issue 11, p1172 

    The article presents an overview of changes which have been seen in the U.S. concerning the legal definitions of the terms coma and death since the 1960s. A discussion of the differences between coma, persistent vegetative state and minimal conscious state is presented. Neurological examinations...

  • The Vegetative State as a Manifestation of a Stable Pathological State. Vainshenker, Yu. I.; Ivchenko, I. M.; Korotkov, A. D.; Melyucheva, L. A.; Kataeva, G. V.; Medvedev, S. V. // Human Physiology;Jan2010, Vol. 36 Issue 1, p118 

    The results of comprehensive monitoring of the state of 25 patients in the vegetative state (prolonged coma) before and after compensating for the factors of secondary brain damage were analyzed and followed up for no less than six months. The primary results showed that the best recovery of...

  • Impossible awakenings. Phillips, Helen // New Scientist;7/7/2007, Vol. 194 Issue 2611, p40 

    The article discusses a variety of unusual medical cases where people with brain damage diagnosed with persistent vegetative state, or PVS, regained consciousness. For example, Terry Wallace awoke after being in a coma for 19 years. Christa Lilly has been in a coma for seven years, but has woken...

  • SUNNY SIDE UP. Holt, Jim // New Republic;2/21/94, Vol. 210 Issue 8, p23 

    Presents an article about coma. Case of Sunny von Bulow who went into coma in 1982; Causes of coma; Characterization of the state of death; Definition and concepts of brain death.

  • A Flicker of Consciousness. Harrell, Eben // Time;11/28/2011, Vol. 178 Issue 21, p42 

    The article discusses research on consciousness in post-coma patients and on persistent vegetative state resulting from brain damage. Studies have found nearly 40% of patients diagnosed as vegetative are minimally conscious, have some awareness, and might improve with treatment. Nobel laureate...

  • A Flicker of Consciousness. Harrell, Eben // Time International (Atlantic Edition);11/28/2011, Vol. 178 Issue 21, p44 

    The article discusses research on consciousness in post-coma patients and on persistent vegetative state resulting from brain damage. Studies have found nearly 40% of patients diagnosed as vegetative are minimally conscious, have some awareness, and might improve with treatment. Nobel laureate...

  • A Flicker of Consciousness. Harrell, Eben // Time International (South Pacific Edition);11/28/2011, Vol. 178 Issue 21, p42 

    The article discusses research on consciousness in post-coma patients and on persistent vegetative state resulting from brain damage. Studies have found nearly 40% of patients diagnosed as vegetative are minimally conscious, have some awareness, and might improve with treatment. Nobel laureate...

  • Dissociations between spatial-attentional processes within parietal cortex: insights from hybrid spatial cueing and change detection paradigms. Vandenberghe, Rik; Gillebert, CĂ©line R. // Frontiers in Human Neuroscience;Jul2013, Vol. 7, p1 

    Spatial cueing has been used by many different groups under multiple forms to study spatial attention processes. We will present evidence obtained in brain-damaged patients and healthy volunteers using a variant of this paradigm, the hybrid spatial cueing paradigm, which, besides single-target...

  • Brain Damage and the Moral Significance of Consciousness. Kahane, Guy; Savulscu, Julian // Journal of Medicine & Philosophy;Feb2009, Vol. 34 Issue 1, p6 

    Neuroimaging studies of brain-damaged patients diagnosed as in the vegetative state suggest that the patients might be conscious. This might seem to raise no new ethical questions given that in related disputes both sides agree that evidence for consciousness gives strong reason to preserve...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics