TITLE

A new dominantly inherited pure cerebellar ataxia, SCA 30

AUTHOR(S)
Storey, E.; Bahlo, M.; Fahey, M.; Sisson, O.; Lueck, C. J.; Gardner, R. J. M.
PUB. DATE
April 2009
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Apr2009, Vol. 80 Issue 4, p408
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Methods: An Australian family of Anglo-Celtic ethnicity manifested a relatively pure, slowly evolving ataxia. Six affected and four unaffected members were personally examined in a standardised fashion. MRI and nerve conduction studies were performed in two. An autosomal genome-wide linkage study was undertaken, and an in silico analysis of potential candidate genes in the linkage region was performed. Results: The six affected members had a relatively pure, slowly evolving ataxia developing in mid to late life, with only minor pyramidal signs and no evidence of neuropathy. All had hypermetric saccades with normal vestibulo-ocular reflex gain. Only one displayed (slight) gaze-evoked nystagmus. MRI showed cerebellar atrophy with preservation of nodulus/uvula and brainstem. Linkage analysis excluded currently known SCAs and identified a logarithm (base 10) of odds score of 3.0 at chromosome 4q34.3-q35.1, distinct from all previously reported loci. In silico prioritisation identified the gene ODZ3 as the most likely contender. Conclusions: SCA 30 is a previously undescribed cause of (relatively) pure adult-onset autosomal dominant cerebellar ataxia. The responsible gene is yet to be determined, but ODZ3 is a plausible candidate.
ACCESSION #
38021532

 

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