TITLE

Monitoring surface-assisted biomolecular assembly by means of evanescent-field-coupled waveguide-mode nanobiosensors

AUTHOR(S)
Gopinath, Subash C. B.; Awazu, Koichi; Fujimaki, Makoto; Sugimoto, Katsuaki; Ohki, Yoshimichi; Komatsubara, Tetsuro; Tominaga, Junji; Kumar, Penmetcha K. R.
PUB. DATE
May 2009
SOURCE
Analytical & Bioanalytical Chemistry;May2009, Vol. 394 Issue 2, p481
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Biological self-assembly is a natural process that involves various biomolecules, and finding the missing partner in these interactions is crucial for a specific biological function. Previously, we showed that evanescent-field-coupled waveguide-mode sensor in conjunction with a SiO2 waveguide, the surfaces which contain cylindrical nanometric holes produced by atomic bombardment, allowed us to detect efficiently the biomolecular interactions. In the present studies, we showed that the assembly of biomolecules can be monitored using the evanescent-field-coupled waveguide-mode biosensor and thus provide a methodology in monitoring assembly process in macromolecular machines while they are assembling. [Figure not available: see fulltext.]
ACCESSION #
37922861

 

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