TITLE

Cerebral Sinovenous Thrombosis

AUTHOR(S)
Hsian-Min Chen; Clayton Chi-Chang Chen; Fong Y. Tsai; Cherng-Gueih Shy; Chen-Hoa Wu; Wen-Shien Chen; Hao-Chun Hung
PUB. DATE
November 2008
SOURCE
Interventional Neuroradiology;2008, Vol. 14 Issue Supp2, p35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cerebral sinovenous thrombosis (CSVT) is an uncommon disorder that affects the dural venous sinus and cerebral vein. In our study, thirty- four patients were examined. Pre and/or post contrast-enhanced CT was done in 28 patients. MRI studies were done in 24 patients. 2-D TOF MR venography (MRV) and contrast-enhanced MRV (CEMRV) were done in 19 cases. Digital subtraction angiography (DSA) was done in 18 patients. Sixteen patients received systemic intravenous heparinization, and 12 received endovascular thrombolytic treatment with urokinase combined with anticoagulant therapy. Neuroimages of CSVT can be acquired by direct visualization of the thrombus within the dural sinus or by parenchymal changes secondary to venous occlusion. As there are some pitfalls to MRI in the diagnosis of CSVT, the combination of MRI and MRV is now the gold standard in the diagnosis of CSVT. Usually, accuracy can be improved by applying 2-D TOF MRV and CE MRV. Furthermore, the source image of MRV is critical in differentiating between normal sinus variations and diseased ones. DSA is the best tool for demonstrating dynamic intracranial circulation in CSVT and mostly is used for endovascular treatment. Systemic intravenous anticoagulant therapy with heparin is accepted as a first line treatment. Except for clinical manifestations after systemic heparinization, abnormal MR findings of parenchymal change can be used to determine when to initiate thrombolytic treatment. Endovascular therapy can be finished at the antegrade flow within the dural sinus and continuous anticoagulation is sufficient to facilitate clinical improvement. Clinical suspicion and excellent neuroimaging are crucial in making the diagnosis of CSVT. Proper management with anticoagulants and/or endovascular thrombolytic therapy is mandatory in preventing propagation of the thrombosis and improving the clinical outcome.
ACCESSION #
37836006

 

Related Articles

  • Use of the Penumbra System 054 plus Low Dose Thrombolytic Infusion for Multifocal Venous Sinus Thrombosis. SIDIQUI, F. M.; PRIDE, G. L.; LEE, J. D. // Interventional Neuroradiology;sep2012, Vol. 18 Issue 3, p314 

    Multifocal cerebral venous sinus thrombosis (CVST) has a high mortality rate especially when patients present with stupor or coma. Medical treatment including anticoagulation raises concerns about the associated high risk of intracerebral hemorrhage. Treatment of multifocal CVST with mechanical...

  • Cerebral venous sinus thrombosis caused by spontaneous intracranial hypotension. Xuemei Qin; Xiaoming Zhang; Qingying Zhang // Neurology Asia;Sep2012, Vol. 17 Issue 3, p227 

    The association of spontaneous intracranial hypotension with cerebral venous sinus thrombosis is rare. We report here a case of extensive cerebral venous sinus thrombosis involving three sinuses following spontaneous intracranial hypotension. The patient presented no other thrombotic risk...

  • Clinical and neuroradiological spectrum of isolated cortical vein thrombosis. Urban, Peter P.; Müller-Forell, W. // Journal of Neurology;Dec2005, Vol. 252 Issue 12, p1476 

    Background Isolated cortical vein thrombosis is only rarely diagnosed, although it may commonly be overlooked. Results We report on four patients with this diagnosis who all presented with focal sensorimotor seizures. The diagnosis was made by a typical CT and MRI-pattern, which is described in...

  • Corpus Callosum Hematoma Secondary to Isolated Inferior Sagittal Sinus Thrombosis. Erbaş, G.; Oner, A. Y.; Akpek, S.; Tokgoz, N. // Acta Radiologica;Dec2006, Vol. 47 Issue 10, p1085 

    A 45‐year‐old female was admitted with headache and vomiting. Cranial computed tomography (CT) demonstrated a callosal hematoma. Magnetic resonance imaging (MRI) showed no venous flow and thrombus replacing the inferior sagittal sinus (ISS) lumen. Under appropriate medical treatment...

  • A different kind of headache in a patient with migraines. AUSMUS, JASON; SHARMA, RAHUL // JAAPA: Journal of the American Academy of Physician Assistants (;Jan2012, Vol. 25 Issue 1, p63 

    The article presents a case study of a 28-year-old female with migraines who consulted the hospital's emergency department (ED) due to left-sided headache. It states that ornithine carbamoyltransferase (OTC) analgesics and rest intermittently eased her headache. It mentions that magnetic...

  • Diagnostic value of T2-Weighted gradient-echo for diagnosis of cerebral venous thrombosis. Shobairi, E.; Shaykh Esmaeli, M. R.; Razazian, N.; Yousefinejad, V.; Rezaie, M. // Pakistan Journal of Medical Sciences;Jan2012, Vol. 28 Issue 1, p62 

    Objectives: The role of MRI has been increased for diagnosis of cerebral venous thrombosis during recent years. In this study the efficacy of T2 Gradient echo for diagnosing cerebral thrombosis has been assessed. Methodology: This study was a descriptive-analytical study, which was focused on...

  • Cerebral sinuvenous thrombosis: a rare complication of Lyme neuroborreliosis. Blažina, Katarina; Miletić, Vladimir; Relja, Maja; Bažadona, Danira // Wiener Klinische Wochenschrift;Jan2015, Vol. 127 Issue 1/2, p65 

    Association between neuroborreliosis and cerebral sinuvenous thrombosis is rare, and it can be made only when other, more common predisposing conditions are excluded. In the case of increased intracranial pressure and confirmed neuroborreliosis, early magnetic resonance venography and...

  • Development of an in vitro model to study clot lysis activity of thrombolytic drugs. Prasad, Sweta; Kashyap, Rajpal S.; Deopujari, Jayant Y.; Purohit, Hemant J.; Taori, Girdhar M.; Daginawala, Hatim F. // Thrombosis Journal;2006, Vol. 4, p14 

    Background: Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients. Several in vitro models have been developed to study clot lytic activity of thrombolytic drugs, but all of these have certain limitations. There is need of an appropriate model to...

  • Current intervention strategies for Cerebral Venous Sinus Thrombosis. Etages, Andre des; Chan, Huan Wee // Internet Journal of Neurosurgery;2007, Vol. 4 Issue 2, p3 

    Intravenous heparin infusion has been the mainstay of treatment for cerebral venous sinus thrombosis (CVST). Surgical and neuroradiological treatment was once an uncommon occurrence. Recent trends, however, have been to employ endovascular or surgical intervention strategies in carefully...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics