TITLE

The Combined Role of Ultrasound and Frozen Section in Surgical Management of Thyroid Nodules Read as Suspicious for Papillary Thyroid Carcinoma on Fine Needle Aspiration Biopsy: A Retrospective Study

AUTHOR(S)
Hee Jung Moon; Jin Young Kwak; Eun-Kyung Kim; Min Jung Kim; Cheong Soo Park; Woung Youn Chung; Eun Ju Son
PUB. DATE
May 2009
SOURCE
World Journal of Surgery;May2009, Vol. 33 Issue 5, p950
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this study was to evaluate the combined role of ultrasound (US) and frozen section (FS) in the surgical management of thyroid nodules that are suspicious for papillary thyroid carcinoma (PTC) on US-guided fine-needle aspiration biopsy (US-FNAB). Between 2006 and 2008, 217 patients with thyroid nodules classified as suspicious for PTC on US-FNAB underwent intraoperative FS and surgery. A thyroid nodule with any suspicious US findings of marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, or taller than wider in shape was defined as positive and that without was defined as negative. FSs were classified as malignant, indeterminate, defer, and benign. We compared the results of US groupings, FS, and final histopathologic diagnosis. Twenty-one (52.5%) of 40 patients with a negative US revealed malignancy. In contrast, 168 (94.9%) of 177 patients with a positive US had malignancy. Fourteen (50%) of 28 patients with benign pathology on FS had malignancy, and 166 (97.6%) of 170 patients with malignancy on FS proved malignancy on histopathology. Of 40 patients with negative US, 13 (92.9%) of 14 with malignancy on FS proved malignancy. The malignancy rate of thyroid nodules read as “suspicious for PTC” on US-FNAB was 87.1%. When a thyroid nodule with “suspicious for PTC” on US-FNAB has suspicious malignant US features, FS may be unnecessary due to a very high risk of malignancy (94.9%). In contrast, when a thyroid nodule read as “suspicious for PTC” on US-FNAB has no suspicious malignant US features, FS can help surgeons determine the extent of surgery.
ACCESSION #
37827199

 

Related Articles

  • Overcoming the Limitations of Integrated Clinical Digital Imaging Solutions. Sinard, John H.; Mattie, Mark E. // Archives of Pathology & Laboratory Medicine;Sep2005, Vol. 129 Issue 9, p1118 

    Context.—Digital imaging is increasingly common in medicine. Vendors of anatomic pathology software have addressed this need by integrating digital image acquisition and storage into their products. While offering a number of advantages, these solutions cannot be easily adapted to...

  • Conformal Bulk Ablation And Therapy Monitoring Using Intracorporeal Image-Treat Ultrasound Arrays. Makin, I. R.; Faidi, W.; Mast, T. D.; Runk, M.; Slayton, M.; Barthe, P. // AIP Conference Proceedings;2005, Vol. 754 Issue 1, p27 

    For thermal treatment of soft tissue, an alternative to HIFU is bulk ablation using unfocused or weakly focused intense ultrasound fields. This approach offers faster ablation of large tissue volumes and can be performed in minimally invasive (e.g., laparoscopic or percutaneous) procedures....

  • Imaging.  // Nature Reviews Drug Discovery;Dec2009, Vol. 8 Issue 12, p1003 

    Imaging technologies are increasingly being applied to aid translational research — for example, by allowing drug–target interactions to be monitored in clinical trials. Our two interviewees this month describe their careers in this field.

  • Evaluation of 3D surface scanners for skin documentation in forensic medicine: comparison of benchmark surfaces. Schweitzer, Wolf; Häusler, Martin; Bär, Walter; Schaepman, Michael // BMC Medical Imaging;2007, Vol. 7, p1 

    Background: Two 3D surface scanners using collimated light patterns were evaluated in a new application domain: to document details of surfaces similar to the ones encountered in forensic skin pathology. Since these scanners have not been specifically designed for forensic skin pathology, we...

  • Meningioangiomatosis: MR imaging and pathological correlation in two cases. Kim, Wha-Young; Kim, In-One; Kim, Woo; Cheon, Jung-Eun; Yeon, Kyung // Pediatric Radiology;Feb2002, Vol. 32 Issue 2, p96 

    Meningioangiomatosis is a rare, benign neoplastic disorder involving the cortex and leptomeninges. The pathological findings are characterised by proliferation of meningothelial cells and leptomeningeal vessels and calcifications within the mass. We experienced two cases of pathologically...

  • Technical advances in ultrasound and MR imaging of carpal tunnel syndrome. Keberle, M.; Jenett, M.; Kenn, W.; Reiners, K.; Peter, M.; Haerten, R.; Hahn, D. // European Radiology;Jul2000, Vol. 10 Issue 7, p1043 

    The aim of this study was to compare the latest ultrasound-array technology to a conventional “high-resolution” transducer, modified MRI technique, and nerve conduction studies (NCS), in the diagnosis of carpal tunnel syndrome (CTS). In 19 normal wrists and 15 wrists with CTS, US...

  • Neuroimaging in Leukodystrophies. Barker, Peter B.; Horská, Alena // Journal of Child Neurology;Aug2004, Vol. 19 Issue 8, p559 

    The application of techniques based on in vivo magnetic resonanceto the study of leukodystrophies is evaluated. Magnetic resonanceimaging (MRI), the most important neuroimaging modality for patientswith leukodystrophies, has proven invaluable for the detection of theextent and etiology of...

  • Automated digital cell morphology.  // MLO: Medical Laboratory Observer;Dec2005, Vol. 37 Issue 12, p40 

    This article presents information on the newly launched DM96, an automated image-analysis system, from CellaVision AB. The DM96 standardizes the manual blood differential by locating and pre-classifying various types of white blood cells in peripheral blood and red blood cell morphology and on a...

  • Stem cells in clinical practice: applications and warnings. Lodi, Daniele; Iannitti, Tommaso; Palmieri, Beniamino // Journal of Experimental & Clinical Cancer Research (17569966);2011, Vol. 30 Issue 1, p9 

    Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics