Toll-like receptors as targets in chronic liver diseases
- Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Acuto, Oreste; Di Bartolo, Vincenzo; Michel, Frédérique; Michel, Frédérique // Nature Reviews Immunology;Sep2008, Vol. 8 Issue 9, p699
The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (establishing immunity or tolerance) following exposure to antigen. This process is made difficult by the narrow margin of self and non-self discrimination, and by the complexity of the genetic...
- A Developmental Timing Switch Promotes Axon Outgrowth Independent of Known Guidance Receptors. // PLoS Genetics;Aug2010, Vol. 6 Issue 8, p1
No abstract available.
- DcR1 expression in endometrial carcinomas. Jordi Tarragona; Nuria Llecha; Maria Santacana; Susana Lopez; Sonia Gatius; David Llobet; Xavier Dolcet; Victor Palomar-Asenjo; Francisco Gonzalez-Tallada; Xavier Matias-Guiu // Virchows Archiv;Jan2010, Vol. 456 Issue 1, p39
AbstractÂ Â The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1...
- Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa. Nayak, Ramesh C.; Keshava, Shiva; Esmon, Charles T.; Pendurthi, Usha R.; Rao, L. Vijaya Mohan // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1
Recent studies have established that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR). FVIIa binding to EPCR may promote the endocytosis of this receptor/ligand complex. Rab GTPases are known to play a crucial role in the endocytic and exocytic pathways of receptors or...
- Understanding RAGE, the receptor for advanced glycation end products. Bierhaus, Angelika; Humpert, Per M.; Morcos, Michael; Wendt, Thoralf; Chavakis, Triantafyllos; Arnold, Bernd; Stern, David M.; Nawroth, Peter P. // Journal of Molecular Medicine;Nov2005, Vol. 83 Issue 11, p876
Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-Î² peptides, and the family of Î²-sheet fibrils have been shown to contribute to a number of chronic diseases such as diabetes, amyloidoses, inflammatory conditions, and tumors by promoting cellular...
- Cell Surface Receptors for Signal Transduction and Ligand Transport: A Design Principles Study. Shankaran, Harish; Resat, Haluk; Wiley, H. Steven // PLoS Computational Biology;Jun2007, Vol. 3 Issue 6, pe101
Receptors constitute the interface of cells to their external environment. These molecules bind specific ligands involved in multiple processes, such as signal transduction and nutrient transport. Although a variety of cell surface receptors undergo endocytosis, the systems-level design...
- Impact of asialoglycoprotein receptor deficiency on the development of liver injury. Lee, Serene M. L.; Casey, Carol A.; McVicker, Benita L.; Hughes, Robin // World Journal of Gastroenterology;3/14/2009, Vol. 15 Issue 10, p1194
The asialoglycoprotein (ASGP) receptor is a well-characterized hepatic receptor that is recycled via the common cellular process of receptor-mediated endocytosis (RME). The RME process plays an integral part in the proper trafficking and routing of receptors and ligands in the healthy cell....
- Now you see it, now you don't! Yokoyama, Wayne M. // Nature Immunology;Aug2000, Vol. 1 Issue 2, p95
Comments on research on the ligands for the mouse NK gene complex-encoded NKG2D activation receptor, published in the August 2000 issue of 'Nature Immunology.' Approach for express ligands; Effects of viral proteins on the ligands.
- Orphan Receptors. // Encyclopedic Reference of Molecular Pharmacology;2004, p702
An encyclopedia entry for the term "orphan receptors" is presented, referring to receptors for which a natural activating ligand has not yet been identified.