İntramusküler Thiocolchicoside Enjeksiyonu Sonrası Gelişen Ensefalopati Tablosu

Uğurel, Burcu; Şahın, Özlem; Öztürk, Vesile
March 2009
Journal of Neurological Sciences;2009, Vol. 26 Issue 1, p97
Academic Journal
Delirium is characterized by acute changes in mental state lasting for hours or days. The etiology of delirium is drug intoxication in approximately 30 % of the patients. Thus the medical history should be assessed carefully and initiation of the symptoms, medications used, changes in dosage or medications currently added to the regimen, drug abuse history such as use of illicit drugs and alcohol and the psychiatric history should also be questioned carefully. Thiocolchicoside (Muscoril®, Muscoflex®) is a myorelaxant medication used in the symptomatic treatment of muscular strains. Since it resembles Cholcicine structurally, adverse effects similar to those of Cholcicine could be encountered and it has depressive and epileptogenic effects on central nervous system. In this report a case of severe encephalopathy developing after intramuscular injection of Thiocolchicoside is presented, admitting to emergency service with delirium and then resolving spontaneously only by supportive treatment. During the assessments, no other etiologic factor that can result in an encephalopathy was detected, and the etiology of this case therefore was thought to be Thiocolchicoside most probably.


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