TITLE

Papel de los estrógenos como reguladores de la actividad del óxido nítrico[sup*]

AUTHOR(S)
Lopez-Jaramillo, Patricio; Teran, Enrique
PUB. DATE
April 1998
SOURCE
Perinatologia y Reproduccion Humana;abr-jun1998, Vol. 12 Issue 2, p67
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
RESUMEN La menopausia representa el final de la vida reproductiva de la mujer y está marcada por la ausencia de ciclos menstruales por un período de al menos un año. La terapia estrogénica sustitutiva tiene un efecto protector sobre el riesgo de mortalidad por enfermedad isquémica coronaria en mujeres postmenopáusicas. Además; cuando ya existe enfermedad coronaria, prolonga la sobrevida de mujeres recibiendo tratamiento. Varios son los mecanismos de acción propuestos para explicar estas acciones de los estrógenos, así tenemos: disminución de los lípidos séricos, menor oxidación lipídica, inhibición del flujo de calcio y acciones vasodilatadoras directas.Los estrógenos tienen además un importante papel a nivel de sistema nervioso central y su deficiencia se ha relacionado con cuadros de depresión involutiva y con el riesgo de desarrollar enfermedad de Alzheimer. También es conocida la relación entre pérdida de la función ovárica y el incremento en la pérdida de masa ósea. En estas dos condiciones, la terapia estrogénica sustitutiva ha mostrado ser efectiva para disminuir las manifestaciones o bien retardar su aparición. Varias acciones de los estrógenos son mediadas por el óxido nítrico, una potente substancia vasoactiva producida por el endotelio vascular y el tejido nervioso. En el presente artículo se revisan las evidencias que sugieren que los efectos protectores del estradiol, así como de la terapia hormonal sustitutiva durante la lmenopáusea, están relacionadas con su capacidad de regular una adecuada producción de NO.PALABRAS GUIA: Estrógenos, menopáusia, óxido nítrico, enfermedad cardiovascular, lípidos, depresión involutiva, osteoporosis.ABSTRACT Menopause repres...
ACCESSION #
3747609

 

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