TITLE

Effect of Systemically Administered Azithromycin in Early Onset Aggressive Periodontitis

AUTHOR(S)
Fujii, Takeo; Pao-Li Wang; Hosokawa, Yoichiro; Shirai, Shinichi; Tamura, Atsumu; Hikita, Kazuhiro; Maida, Takeo; Ochi, Morio; Baehni, Pierre C.
PUB. DATE
September 2004
SOURCE
Periodontal Practice Today;2004, Vol. 1 Issue 4, p321
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Azithromycin is a macrolide which possesses a strong antimicrobial activity against Gram-positive and Gram-negative pathogens. In the present study, we studied the effect of azithromycin as an adjunct to non-surgical treatment in early onset aggressive periodontitis. Initial treatment consisting of oral instructions and full-mouth scaling and root planing was performed over a 2-month period. Patients were then administered with azithromycin, 500 mg per os, 1×/day, for 3 days. Professional mechanical tooth cleaning was performed once every two weeks during the initial preparation. Initial treatment was considered as completed when the gingival index was < 1. The probing pocket depth, percentage of periodontal pockets with depth ≥ 4 mm, and the rate of bleeding on probing improved following treatment. The duration of the treatment was 4.7 ± 3.2 months. Another group of patients received the same initial treatment but without azithromycin. The duration of the treatment for this group was 11.2 ± 4.9 months. These results indicate that azithromycin may be useful for the treatment of early onset periodontitis.
ACCESSION #
37379144

 

Related Articles

  • Synthesis and antimicrobial activity of Dihydropyrimidine derivatives. Mishra, Manish Kumar; Gupta, A. K.; Negi, S. // Drug Invention Today;Aug2010, Vol. 2 Issue 8, p387 

    6-methyl-2-oxo N-(4-oxo-2-substituted phenyl-1,3-thiazolidin-3-yl)-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide have been synthesized and compound 4b and 4e has significant effect against Streptococcus aureus for gram positive and 4b and 4d has significant effect against...

  • Applying antimicrobial pharmacodynamics to resistant gram-negative pathogens. Scheetz, Marc H.; Hurt, Kristin M.; Noskin, Gary A.; Oliphant, Catherine M. // American Journal of Health-System Pharmacy;7/15/2006, Vol. 63 Issue 14, p1346 

    Purpose. Guided antibiotic adjustment for the treatment of multidrug-resistant, gram-negative pathogens is explored. Summary. Multidrug-resistant pathogens are being isolated with increasing frequency, while the production of novel agents to circumvent resistance has slowed to a near halt....

  • Distribution of Macrolide, Lincosamide, Streptogramin, Ketolide and Oxazolidinone (MLSKO) Resistance Genes in Gram-negative Bacteria. Roberts, Marilyn C. // Current Drug Targets - Infectious Disorders;Sep2004, Vol. 4 Issue 3, p207 

    A number of different mechanisms of macrolide resistance have been described in Gram-negative bacteria. These include 16 acquired genes (esterases, phosphorylases, rRNA methylases, and effluxes) and include those thought to be unique to Gram-negative bacteria (both esterases and two of the...

  • Efficacy of subantimicrobial dosing with doxycycline. Greenstein, Gary; Lamster, Ira // Journal of the American Dental Association (JADA);Apr2001, Vol. 132 Issue 4, p457 

    Addresses the role of subantimicrobial dosing with doxycycline or SDD, in the treatment of chronic periodontitis. Enhancement of the efficacy of scaling and root planing; Most accurate way to express the degree of improvement in probing depth reduction; Clinical attachment that can be gained...

  • Antimicrobial susceptibility pattern of bacterial isolates from surgical wound infections in Tertiary Care Hospital in Allahabad, India. Verma, Amit Kumar; Kapoor, A. K.; Bhargava, Anodita // Internet Journal of Medical Update;Jan2012, Vol. 7 Issue 1, p27 

    The aim of present study to analyze the occurrence and in-vitro antimicrobial susceptibility of bacterial pathogens isolated from surgical wound infections. Specimens from a total of 129 patients undergoing either emergency or elective surgery were collected from infected sites or stitch lines...

  • Challenges in Identifying New Antimicrobial Agents Effective for Treating Infections with Acinetobacter baumannii and Pseudomonas aeruginosa. Rice, Louis B. // Clinical Infectious Diseases;9/1/2006 Supplement, Vol. 43, pS100 

    Acinetobacter baumannii and Pseudomonas aeruginosa are gram-negative pathogens that target immunocompromised patients. They express a variety of determinants that confer resistance to a broad array of antimicrobial agents. Mechanisms of resistance include impaired entry through the bacterial...

  • Azithromycin Extended Release: A Review of its Use in the Treatment of Acute Bacterial Sinusitis and Community-Acquired Pneumonia in the US. Swainston, Tracy; Kean, Susan J. // Drugs;2007, Vol. 67 Issue 5, p773 

    Azithromycin is a macrolide antibacterial agent. The novel microspheres oral extended-release formulation (Zmaxâ„¢) is the first antibacterial drug approved in the US for administration as a single dose in adult patients with mild to moderate acute bacterial sinusitis (ABS) or...

  • In Vitro Activity of Doripenem. Sahm, Daniel // Clinical Infectious Diseases;Aug2009 Supplement 1, Vol. 49, pS11 

    Doripenem is a carbapenem antibiotic that covers a wide range of gram-positive and gram-negative pathogens. In vitro studies have provided insight into certain features of doripenem's activity profile that may have particular relevance in the clinical setting. For instance, in vitro data...

  • Peritonitis More Likely to Recur with S. aureus.  // Kidney;Mar/Apr99, Vol. 8 Issue 2, p74 

    Presents an abstract of the study 'Differing outcomes of gram-positive and gram-negative peritonitis,' by L. Troidle, N. Gorban-Brennan, A. Kliger, et al.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics