TITLE

Nanomaterials in fluorescence-based biosensing

AUTHOR(S)
Wenwan Zhong
PUB. DATE
May 2009
SOURCE
Analytical & Bioanalytical Chemistry;May2009, Vol. 394 Issue 1, p47
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fluorescence-based detection is the most common method utilized in biosensing because of its high sensitivity, simplicity, and diversity. In the era of nanotechnology, nanomaterials are starting to replace traditional organic dyes as detection labels because they offer superior optical properties, such as brighter fluorescence, wider selections of excitation and emission wavelengths, higher photostability, etc. Their size- or shape-controllable optical characteristics also facilitate the selection of diverse probes for higher assay throughput. Furthermore, the nanostructure can provide a solid support for sensing assays with multiple probe molecules attached to each nanostructure, simplifying assay design and increasing the labeling ratio for higher sensitivity. The current review summarizes the applications of nanomaterials—including quantum dots, metal nanoparticles, and silica nanoparticles—in biosensing using detection techniques such as fluorescence, fluorescence resonance energy transfer (FRET), fluorescence lifetime measurement, and multiphoton microscopy. The advantages nanomaterials bring to the field of biosensing are discussed. The review also points out the importance of analytical separations in the preparation of nanomaterials with fine optical and physical properties for biosensing. In conclusion, nanotechnology provides a great opportunity to analytical chemists to develop better sensing strategies, but also relies on modern analytical techniques to pave its way to practical applications.
ACCESSION #
37371682

 

Related Articles

  • Detection of nano-confined DNA using surface-plasmon enhanced fluorescence. Cloutier, Sylvain G.; Lazareck, Adam D.; Xu, Jimmy // Applied Physics Letters;1/2/2006, Vol. 88 Issue 1, p013904 

    Surface-plasmon resonance (SPR)-induced enhanced fluorescence was used to detect the presence of fluorescent TOTO-1 bis-intercalated lambda-DNA complexes introduced into a periodic nanopore array. As we show, the proposed technique allows a high detection sensitivity by providing a strong...

  • NEW PLATFORM OF BIOSENSORS BASED ON FLUORESCENCE DETECTION FOR ENVIROMENTAL APPLICATIONS. Cano, Juan Bernardo; Buonasera, Katia; Pezzotti, Gianni // Revista Politécnica;jul-dic2011, Vol. 7 Issue 13, p124 

    Multilights is an instrument for fluorescence detection on biosensor applications, It permits working simultaneously with different types of biomediators (that can be fluorophores or photosynthetic). This article describes the different systems that form the instrument, like measurement cells,...

  • Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications. Matos Pires, Nuno Miguel; Tao Dong; Hanke, Ulrik; Hoivik, Nils // Sensors (14248220);Aug2014, Vol. 14 Issue 8, p15458 

    The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main...

  • Optical Characterization of Europium Tetracycline Complex in the presence of Low Density Lipoprotein and its Applications. de Oliveira Silva, Flávia Rodrigues; Monteiro, Andrea Moreira; Neto, Antônio M. Figueiredo; Gidlund, Magnus A.; Gomes, Laércio; Junior, Nilson Dias Vieira; Courrol, Lilia Coronato // AIP Conference Proceedings;4/15/2008, Vol. 992 Issue 1, p749 

    Development of native Low Density Lipoprotein (LDL) biosensors is of great importance in clinical analysis because the LDL concentration, which is the main carrier of cholesterol, in the plasma, is a fundamental parameter for the prevention and diagnosis of a number of clinical disorders such as...

  • Application of anodized aluminum in fluorescence detection of biological species. Takmakov, Pavel; Vlssiouk, Ivan; Smirnov, Sergei // Analytical & Bioanalytical Chemistry;Aug2006, Vol. 385 Issue 5, p954 

    Thin nanoporous alumina obtained by anodization of aluminum films offers promising advantages for application in fluorescence-based biological sensors including convenient preparation, increased density of binding sites, and improved collection efficiency of fluorescence. These advantages are...

  • Iron specificity of a biosensor based on fluorescent pyoverdin immobilized in sol-gel glass. Yoder, Michael F.; Kisaalita, William S. // Journal of Biological Engineering;2011, Vol. 5 Issue 1, p4 

    Two current technologies used in biosensor development are very promising: 1. The sol-gel process of making microporous glass at room temperature, and 2. Using a fluorescent compound that undergoes fluorescence quenching in response to a specific analyte. These technologies have been combined to...

  • Fluorescence biosensor for inorganic pyrophosphatase activity. Zhang, Ying; Guo, Yajuan; Zhao, Mengmeng; Lin, Cuiying; Lin, Zhenyu; Luo, Fang; Chen, Guonan // Analytical & Bioanalytical Chemistry;Feb2017, Vol. 409 Issue 4, p999 

    A highly sensitive and selective fluorescence biosensor for inorganic pyrophosphatase (PPase) activity has been developed based on special click ligation trigger hyperbranched rolling circle amplification (CLT-HRCA). Pyrophosphate ion (PPi) can coordinate with Cu to form stable PPi/Cu complex...

  • The Use of Whole-Cell Biosensors to Detect and Quantify Compounds or Conditions Affecting Biological Systems. Hansen, L. H.; Sørensen, S. J. // Microbial Ecology;Dec2001, Vol. 42 Issue 4, p483 

    A new and promising technique in microbial ecology and environmental biology is the use of whole-cell bacterial biosensors. This minireview describes the use of such biosensors for detection and quantification of various compounds and other conditions affecting bacterial expression of different...

  • New Uses for Biosensors.  // Futurist;May/Jun88, Vol. 22 Issue 3, p54 

    Speculates on the use of biosensors. Limitations of current sensing technologies, suggesting biosensors could provide sensing speeds far greater than is currently capable; Speculation about the future use of biosensors, according to a report by market-research firm Frost & Sullivan, noting a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics