A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
- Interaction between clopidogrel and proton pump inhibitors: A clinical overview. Nagavi, Jinesh B.; Gurupadayya, B. M. // International Journal of Pharmacy;Jul2014, Vol. 4 Issue 3, p141
Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown. Over recent years there has been much debate about whether some or all proton pump inhibitors might reduce the effectiveness of...
- DRUG INTERACTIONS WITH DIAZEPAM. Bojanić, Zoran; Bojanić, Novica; Bojanić, Vladmila; Lazović, Marko // Acta Medica Medianae;Jun2011, Vol. 50 Issue 2, p76
Diazepam is a benzodiazepine derivative with anxyolitic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, antitremor, and amnestic activity. It is metabolized in the liver by the cytochrome P (CYP) 450 enzyme system. Diazepam is N-demethylated by CYP3A4 and CYP2C19 to the active...
- Effects of CYP Induction by Rifampicin on Tamoxifen Exposure. Binkhorst, L; van Gelder, T; Loos, W J; de Jongh, F E; Hamberg, P; Moghaddam-Helmantel, I M Ghobadi; de Jonge, E; Jager, A; Seynaeve, C; van Schaik, R H N; Verweij, J; Mathijssen, R H J // Clinical Pharmacology & Therapeutics;Jul2012, Vol. 92 Issue 1, p62
Tamoxifen undergoes biotransformation into several metabolites, including endoxifen. Differences in metabolism contribute to the interindividual variability in endoxifen concentrations, potentially affecting treatment efficacy. We evaluated the effects of cytochrome P450 (CYP) induction by...
- Warning over PPI use after an MI. Anekwe, Lilian // Pulse;9/22/2010, Vol. 70 Issue 27, p8
The article focuses on the result of the study which shows that proton pump inhibitors prescription to patients with myocardial infarction increases the risk of cardiovascular events.
- Safety of proton pump inhibitors. Elliott, William T. // Clinical Oncology Alert;Nov2010 Supplement, p1
This article focuses on a Danish study which examined the safety of proton pump inhibitors (PPIs) in patients who were hospitalized for myocardial infarction (MI). Results of the study showed that there were similar rates of death or rehospitalization among patients who were discharged on a...
- Combining PPI and aspirin increases CVD event risk. // Pulse;6/8/2011, Vol. 71 Issue 21, p9
The article reports on the result of the study which suggests that prescribing proton-pump inhibitors to myocardial infarction patients on aspirin can increase their risk of cardiovascular events.
- Proton Pump Inhibitors and Clopidogrel. Karpman, Harold L. // Internal Medicine Alert;6/29/2011, Vol. 33 Issue 12, p92
Proton pump inhibitor use in clopidogreltreated post-percutaneous coronary intervention patients was not associated with an increased risk of all-cause death, nonfatal myocardial infarction, repeat revascularization, or major adverse cardiovascular events.
- Proton pump inhibitors linked to heart attack risk. // Gastrointestinal Nursing;Jul/Aug2015, Vol. 13 Issue 6, p6
The article cites Dr. Andy Lazris, who runs a practice in Columbia, Maryland who disputes a study which show that people who take proton pump inhibitors (PPIs) drugs commonly used for heartburn, are at greater risk of suffering a heart attack.
- Association with raised risk of myocardial infarction. // BMJ: British Medical Journal;6/20/2015, Vol. 350 Issue 8013, ph3220
The article discusses research published in an issue of "PLoS One" journal which investigated myocardial infarction risk in individuals using proton pump inhibitors.