Upregulating SOX9 expression inhibits melanoma cell development, spread

Adams, Stacey L.; Harris, Jason; Southall, Jennifer
April 2009
Hem/Onc Today;4/10/2009, Vol. 10 Issue 7, p29
The article discusses a study on the role of an increased expression of the protein sex determining region Y-box 9 (SOX9) in inhibiting the development and spread of melanoma cells.


Related Articles

  • Loss of AMPKα1 Expression Is Associated with Poor Survival in Melanoma Patients. Bhandaru, Madhuri; Martinka, Magdalena; Li, Gang; Rotte, Anand // Journal of Investigative Dermatology;Jun2014, Vol. 134 Issue 6, p1763 

    A letter to the editor is presented regarding the loss of AMP-activated protein kinaseα1 expression which is linked with poor quality survival in patients with melanoma.

  • Expression of the Anti-Apoptotic Protein BAG3 in Human Melanomas. Franco, Renato; Scognamiglio, Giosuè; Salerno, Vincenzo; Sebastiani, Adolfo; Cennamo, Giovanni; Ascierto, Paolo A; Botti, Gerardo; Turco, Maria C; Rosati, Alessandra // Journal of Investigative Dermatology;Jan2012, Vol. 132 Issue 1, p252 

    A letter to the editor is presented regarding the expression of BAG3, an anti-apoptotic protein, in human melanomas.

  • Cloning and Characterization of the Expression Pattern of a Novel Splice Product MIA (Splice) of Malignant Melanoma-derived Growth-inhibiting Activity (MIAY CD-RAP). Hau, Peter; Wise, Petra; Bosserhoff, Anja-Katrin; Blesch, Armin; Jachimczak, Piotr; Tschertner, Ines; Bogdahn, Ulrich; Apfel, Rainer // Journal of Investigative Dermatology;Sep2002, Vol. 119 Issue 3, p562 

    Melanoma-inhibiting activity/cartilage-derived retinoic acid-sensitive protein, a 11 kDa protein, is mainly expressed in cartilage during embryogenesis, and is related to invasion, metastasis, and immunomodulation of melanoma and glioma cells in vivo and in vitro . Here, we describe an...

  • In vivo effects in melanoma of ROCK inhibition-induced FasL overexpression. Teiti, Iotefa; Florie, Bertrand; Pich, Christine; Gence, Rémi; Lajoie-Mazenc, Isabelle; Rochaix, Philippe; Favre, Gilles; Tilkin-Mariamé, Anne-Françoise; Kaminska, Bozena; Umansky, Viktor; Bonavida, Benjamin // Frontiers in Oncology;Jul2015, p1 

    Ectopic Fas-ligand (FasL) expression in tumor cells is responsible for both tumor escape through tumor counterattack of Fas-positive infiltrating lymphocytes and tumor rejection though inflammatory and immune responses. We have previously shown that RhoA GTPase and its effector ROCK negatively...

  • Vaccine, heat shock show promise for melanoma. Moyer, Paula // Dermatology Times;Jul2002, Vol. 23 Issue 7, p31 

    Focuses on the vaccination of melanoma patients with heat shock proteins. Cycles of treatment; Activation of anti-melanoma specific T cells; Implication for the clinical treatment of melanoma.

  • Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. Chen, Ying; Kramer, Debora L; Li, Fengzhi; Porter, Carl W // Oncogene;8/7/2003, Vol. 22 Issue 32, p4964 

    We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis in human melanoma SK-MEL-28 cells via a series of events that include mitochondrial release of cytochrome c and activation of the caspase cascade. Upstream to these...

  • A novel Bcl-x splice product, Bcl-xAK, triggers apoptosis in human melanoma cells without BH3 domain. Hossini, A M; Geilen, C C; Fecker, L F; Daniel, P T; Eberle, J // Oncogene;4/6/2006, Vol. 25 Issue 15, p2160 

    Pro- and antiapoptotic proteins of the large Bcl-2 family are critical regulators of apoptosis via the mitochondrial pathway. Whereas antiapoptotic proteins of the family share all four Bcl-2 homology domains (BH1–BH4), proapoptotic members may lack some of these domains, but all so far...

  • Protein Glycosylation as Marker of Melanoma Progression. Lityńska, Anna; Przybyło, Małgorzata; Hoja-Łukowicz, Dorota; Pocheć, Ewa; Kremser, Marcelina; Ciołczyk-Wierzbicka, Dorota; Łabędź, Maria; Laidler, Piotr // Current Cancer Therapy Reviews;2008, Vol. 4 Issue 2, p144 

    A lot of experimental data has been produced which suggests that there is a crucial role for glycans during the different stages of melanoma progression. Malignant transformation is associated with various alterations in the glycosylation pattern of the protein glycans. The most common changes...

  • Differential Expression of a Novel Gene in Response to hsp27 and Cell Differentiation in Human Keratinocytes. Hell-Pourmojib, Mojgan; Neuner, Peter; Fischer, Heinz; Rezaie, Sassan; Kindås-Mügge, Ingela; Knobler, Robert; Trautinger, Franz // Journal of Investigative Dermatology;Jul2002, Vol. 119 Issue 1, p154 

    The 27 kDa heat shock protein (hsp27) is expressed in keratinocytes in a differentiation-related pattern. Keratinocyte differentiation involves a coordinated program of expression and interaction of specific differentiation-related genes and proteins. To investigate the functional role of hsp27...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics