Retrospektyvinė listerinių meningitų studija suaugusiesiems ir literatūros apžvalga

Tumosaitė, I.; Pakalnienė, J.; Ambraška, L.; Vieželis, K.; Mickienė, A.
March 2009
Neurologijos Seminarai;2009, Vol. 13 Issue 1, p19
Academic Journal
Listeria monocytogenes is a foodborne pathogen that causes infection in humans. It can also be transmitted to neonate from the mother through transplacental way or exposure to vaginal carriage during birth. The most common form of listeriosis in adults is meningitis. Listeria monocytogenes is the third or fourth most common cause of community acquired bacterial meningitis in adults in North America and Europe. It causes 11-20% of all bacterial meningitis in people older than 50 years. About 70% of listeriosis in adults occurs among immunocompromised patients, such as individuals with malignancies or organ transplants, taking immunosuppressive therapy and those with HIV/AIDS infection, diabetes, alcoholism, and liver insufficiency. Listeriosis is a serious public health problem because of its high mortality which can be as high as 30% and more despite adequate antibacterial treatment. Ampicillin is the first choice therapy for listeriosis, sometimes given in combination with gentamicin. 3rd generation cefalosporins are ineffective against listeria. Prophylaxis of listeriosis is non-specific, there's no vaccine against Listeria monocytogenes. This article presents a case report of severe Listeria monocytogenes meningoencephalitis together with case series of invasive listeriosis in adults treated at Kaunas 2nd Clinical Hospital from 1999 till 2008, and gives a comprehensive review of the literature.


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