TITLE

Visceral childhood leishmaniasis in southern Turkey: experience of twenty years

AUTHOR(S)
Dursun, Oğuz; Erişir, Seyhan; Yeşilipek, Akif
PUB. DATE
January 2009
SOURCE
Turkish Journal of Pediatrics;Jan/Feb2009, Vol. 51 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
One hundred and one children with visceral leishmaniasis (VL) who admitted to Akdeniz University Hospital during a 20-year period were analyzed. Median age of the patients was 3 years (range: 5.5 months-13 years). The most common symptoms at presentation were fever, pallor and abdominal distension. Splenomegaly was found in all of the patients while hepatomegaly was present in 98%. Anemia (96%), leukopenia (74%) and thrombocytopenia (56%) were the main laboratory abnormalities. Thirty-three (33%) of the patients were pancytopenic on admission. Bone marrow smear was positive for leishmania in 91% of the patients. Seventy-four patients were treated with antimony ± pentamidine and 27 with amphotericin B. Three of our patients died because of secondary infections and hemorrhage. Relapse was observed in two patients. No patient showed post kala-azar dermal leishmaniasis findings. We conclude that VL should be considered in patients with prolonged fever, hepatosplenomegaly and cytopenia who live in an endemic region. Amphotericin B is a therapeutic agent as effective as pentavalent antimony compounds and could be preferred.
ACCESSION #
37275665

 

Related Articles

  • Immune haemolytic anaemia due to visceral leishmaniasis in a young child: Reply. Dotis, John; Roilides, Emmanuel // European Journal of Pediatrics;2003, Vol. 162 Issue 6, p445 

    Presents the views of the authors on the incidence of immune haemolytic anemia due to visceral leishmaniasis. Need of an urgent and low-cost approach to the treatment of leishmaniasis; Use of the immunochromatographic dipstick test for the diagnosis of leishmaniasis; Difficulties in the use of...

  • New Treatment Approach in Indian Visceral Leishmaniasis: Single-Dose Liposomal Amphotericin B Followed by Short-Course Oral Miltefosine. Sundar, Shyam; Rai, M.; Chakravarty, J.; Agarwal, D.; Agrawal, N.; Vaillant, Michel; Olliaro, Piero; Murray, Henry W. // Clinical Infectious Diseases;10/15/2008, Vol. 47 Issue 8, p1000 

    Background. In Bihar, India, home to nearly one-half of the world's burden of visceral leishmaniasis, drug resistance has ended the usefulness of pentavalent antimony, which is the traditional first-line treatment. Although monotherapy with other agents is available, the use of 2 drugs with...

  • Management of visceral leishmaniasis: Indian perspective. Agrawal, S.; Rai, M.; Sundar, S. // Journal of Postgraduate Medicine;Oct-Dec2005 Supplement, Vol. 51, pS53 

    Diagnosis and treatment of Indian visceral leishmaniasis (VL) is extremely unsatisfactory. For diagnosis, demonstration of parasites in splenic/marrow smears remains the gold standard, though k39 rapid strip test is a useful method in regions where access to parasite demonstration is difficult....

  • Failure of Pentavalent Antimony in Visceral Leishmaniasis in India: Report from the Center of... Sundar, Shyam; More, Deepak K.; Singh, Manoj K.; Singh, Vijay P.; Sharma, Sashi; Makharia, Anand; Kumar, Prasanna C. K.; Murray, Henry W. // Clinical Infectious Diseases;10/1/2000, Vol. 31 Issue 4, p1104 

    Reports on the large-scale therapeutic failure of conventional treatment of pentavalent antimony (Sb) in patients with visceral leishmaniasis (kala-azar) in India. Symptoms of kala-azar; Development of cardiotoxicity in ten percent of patients consistent with Sb-induced effects; Abandonment of...

  • Impact of amphotericin-B in the treatment of kala-azar on the incidence of PKDL in Bihar, India. Thakur, C. P.; Kumar, Amit; Mitra, Gaurab; Thakur, Shabnam; Sinha, P. K.; Das, P.; Bhattacharya, S. K.; Sinha, Arun // Indian Journal of Medical Research;Jul2008, Vol. 128 Issue 1, p38 

    Background & objectives: Of the two reservoirs of infection of kala-azar Le., patients of kala-azar and post kala-azar dermal leishmaniasis (PKDL), PKDL provides easy access for the sandfly to pick up the parasites. In the last epidemic of 1977 in India, the importance of PKDL as a potential...

  • Kala-Azar Elimination in Bihar: Adoption of Newer Evidence-based Strategies Required for Elimination. Soni, Prashant; Mishra, Ragini; Kumar, Ganga; Pandey, Prabhat; Kumar, Prashant // Middle East Journal of Scientific Research;2013, Vol. 17 Issue 9, p1220 

    Kala-azar i.e, Visceral Leishmaniasis (VL) is a menace to Bihar, affecting large number of population. As per WHO, one-third cases of Kala-azar are reported from Bihar itself. Diagnosis and case detection is done by rk39. Miltefosine has been rolled out in 16 highly endemic districts of Bihar;...

  • Visceral leishmaniasis in a patient with Down syndrome. Colomba, Claudia; Saporito, Laura; Giordano, Salvatore; Infurnari, Laura; Ajovalasit, Patrizia; Titone, Lucina // European Journal of Pediatrics;Feb2006, Vol. 165 Issue 2, p140 

    The article focuses on a case of visceral leishmaniasis that occurred in a child with a cardiopathic condition and Down syndrome. After undergoing a surgical intervention for congenital cardiopathy, a 6-month-old child with Down syndrome returned to paediatric cardiosurgery department with...

  • Antiretrovirals.  // Reactions Weekly;10/20/2007, Issue 1174, p6 

    The article describes the case of a 46-year-old man with AIDS who developed post-kala-azar dermal leishmaniasis as an immune reconstitution syndrome during treatment with antiretrovirals in unspecified dosages, duration and reaction onset. It says that the patient was diagnosed with AIDS in...

  • Investments in Research and Surveillance Are Needed to Go Beyond Elimination and Stop Transmission of Leishmania in the Indian Subcontinent. Olliaro, Piero L.; Shamsuzzaman, Tushar A. K. M.; Marasini, Baburam; Dhariwal, A. C.; Be-Nazir, Ahmed; Mondal, Dinesh; Banjara, Megha Raj; Das, Pradeep; Sundar, Shyam; Rijal, Suman; Arana, Byron; Alvar, Jorge; Argaw, Daniel; Peeling, Rosanna W.; Kroeger, Axel; Matlashewski, Greg // PLoS Neglected Tropical Diseases;1/26/2017, Vol. 11 Issue 1, p1 

    The article offers information on the Kala-azar Elimination Programme focusing to eliminate visceral leishmaniasis as a public health problem. It mentions improved treatments for visceral leishmaniasis offered through liposomal amphotericin B, paromomycin, and miltefosine. It also mentions that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics