TITLE

Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging

AUTHOR(S)
Li, Hui; Zhang, Lu; Wang, Xueyan; Wang, Tailing; Wang, Baoen; Zhao, Xinyan; Luo, Shuqian
PUB. DATE
March 2009
SOURCE
Applied Physics Letters;3/23/2009, Vol. 94 Issue 12, p124101
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
X-ray diffraction enhanced imaging (DEI) is a phase contrast technique that generates excellent contrast of biological soft tissues compared to conventional absorption radiography. We explore the application of DEI in the diagnosis of hepatic fibrosis. The produced refraction contrast images of fibrous rat liver samples show clearly abnormal liver architectures. Moreover, by comparing to histological pictures, different stages of fibrosis are discriminated, and the corresponding morphological features are analyzed. Besides, quantitative analyses of texture features are presented. The results reported herein show that DEI can be a potential noninvasive technique to diagnose and stage hepatic fibrosis.
ACCESSION #
37259603

 

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