Monitoring of cell cultures with LTCC microelectrode array

Ciosek, P.; Zawadzki, K.; Lopacinska, J.; Skolimowski, M.; Bembnowicz, P.; Golonka, L. J.; Brzózka, Z.; Wróblewski, W.
April 2009
Analytical & Bioanalytical Chemistry;Apr2009, Vol. 393 Issue 8, p2029
Academic Journal
Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes. [Figure not available: see fulltext.]


Related Articles

  • Human cell cultures as an assay for the toxicity of antioxidants Goto, M.; Mochida, K.; Saito, K. // Bulletin of Environmental Contamination & Toxicology;Oct1985, Vol. 35 Issue 4, p427 

    No abstract available.

  • ERRATUM.  // Southwestern Entomologist;Mar2013, Vol. 38 Issue 1, p149 

    A correction to the article "Toxicity to adult brown stink bug (Hemiptera: Pentatomidae) in a glass-vial bioassay of selected insecticide mixtures" that was published in the 2012 issue is presented.

  • Phototoxicity of Ultraviolet (UV) Radiation: Evaluation of UV-Blocking Efficiency of Intraocular Lens (IOL) Materials Using Retinal Cell Culture and in vitro Bioassays. Youn, H. Y.; Cullen, A. P.; Chou, B. R.; Sivak, J. G. // Open Toxicology Journal;2010, Vol. 4, p13 

    This work involves the evaluation of UV blocking efficiency of commercially available intraocular lens (IOL) materials using a retinal cell culture and a biological in vitro model that was developed in a previous study, as an effort to examine the sensitivity of this in vitro approach for...

  • A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing. Mielke, Hans; Anger, Lennart; Schug, Markus; Hengstler, Jan; Stahlmann, Ralf; Gundert-Remy, Ursula // Archives of Toxicology;Jun2011, Vol. 85 Issue 6, p555 

    Our study was performed in the context of an in vitro primary hepatic cell culture as an alternative for the in vivo cancerogenic bioassay. The 29 substances which are to be used in the in vitro primary hepatic cell culture have been tested in 2-year bioassays and a 14-day short term study. The...

  • Cytotoxicity of chlorhexidine-hydrogen peroxide combination in different concentrations on cultured human periodontal ligament fibroblasts. Mirhadi, Hosein; Azar, Mohammad Reza; Abbaszadegan, Abbas; Geramizadeh, Bita; Torabi, Shima; Rahsaz, Marjan // Dental Research Journal;Dec2014, Vol. 11 Issue 6, p645 

    Background: A strong antimicrobial synergism between chlorhexidine (CHX) and hydrogen peroxide (H2O2) has been reported, but there is not enough data on the cytotoxicity of this combination. The primary aim of this study was to evaluate the cytotoxicity of CHX-H2O2 combination in different...

  • Screening of anti-dengue activity in methanolic extracts of medicinal plants. Tang, Leon I. C.; Ling, Anna P. K.; Koh, Rhun Y.; Chye, Soi M.; Voon, Kenny G. L. // BMC Complementary & Alternative Medicine;2012, Vol. 12 Issue 1, p1 

    Background: Dengue fever regardless of its serotypes has been the most prevalent arthropod-borne viral diseases among the world population. The development of a dengue vaccine is complicated by the antibody-dependent enhancement effect. Thus, the development of a plant-based antiviral...

  • Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells. Victor Kuete, Victor Kuete; Voukeng, Igor K.; Tsobou, Roger; Mbaveng, Armelle T.; Wiench, Benjamin; Beng, Veronique P.; Efferth, Thomas // BMC Complementary & Alternative Medicine;2013, Vol. 13 Issue 1, p250 

    Background: Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer. Evidence of the cytotoxicity of Cameroonian plants against cancer cell lines including MDR phenotypes is been intensively...

  • Development of a Protocol for Human Adipose Stem Cell Culture in CO2 Independent Medium and Perfusion Bioreactor. Silva, A. R. P.; Paula, A. C. C.; Zonari, A.; Martins, T. M. M.; Goes, A. M.; Pereira, M. M. // Journal of Tissue Science & Engineering;Special2012, Vol. 3 Issue S, Special section p1 

    Advances in research on stem cells derived from human Adipose tissue (hASC) may allow its use for bone tissue engineering. In such context, it is important to standardize a methodology to culture cells in high quantity. Bioreactors, in which cells are cultured in three-dimension, mimic the...

  • A modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture. Goepfert, Christiane; Blume, Grit; Faschian, Rebecca; Meyer, Stefanie; Schirmer, Cedric; Müller-Wichards, Wiebke; Müller, Jörg; Fischer, Janine; Feyerabend, Frank; Pörtner, Ralf // BMC Proceedings;12/4/2013, p1 

    The article presents a study which discusses modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture. Topics discussed include replacement of animal trials by cell culture assays, concept of the flow-chamber bioreactor, two types of bioreactors such as closed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics