TITLE

Stem Cells from Deciduous Tooth Repair Mandibular Defect in Swine

AUTHOR(S)

Zheng, Y.; Liu, Y.; Zhang, C. M.; Zhang, H. Y.; Li, W. H.; Shi, S.; Le, A. D.; Wang, S. L.

PUB. DATE

March 2009

SOURCE

Journal of Dental Research;Mar2009, Vol. 88 Issue 3, p249

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-size bone defects generated in swine mandible models. Our results indicated that stem cells from miniature pig deciduous teeth, an autologous and easily accessible stem cell source, were able to engraft and regenerate bone to repair critical-size mandibular defects at 6 months post-surgical reconstruction. This pre-clinical study in a large-animal model, specifically swine, allows for testing of a stem cells/scaffold construct in the restoration of orofacial skeletal defects and provides rapid translation of stem-cell-based therapy in orofacial reconstruction in human clinical trials.

ACCESSION #

37212379

Tags: DECIDUOUS teeth;  STEM cells;  TISSUE engineering;  BONES -- Abnormalities;  MANDIBLE -- Abnormalities;  SWINE as laboratory animals

 

Related Articles

• Want Stem Cells? Check Baby Teeth.  // Journal of Dental Hygiene;Summer2003, Vol. 77 Issue 3, p156 

  Details research findings which shows that baby teeth contain stem cells that could provide a life-saving source of tissue. Potential of stem cells from baby teeth to be used in stem therapies, such as stem-cell transplantation and tissue engineering.

• Dentin-derived BMP-2 and Odontoblast Differentiation. Casagrande, L.; Demarco, F. F.; Zhang, Z.; Araujo, F. B.; Shi, S.; N�r, J. E. // Journal of Dental Research;Jun2010, Vol. 89 Issue 6, p603 

  It is known that stem cells from exfoliated deciduous teeth (SHED) can be induced to differentiate into odontoblasts. However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains unclear. The hypothesis underlying this work is that...

• SHED Differentiate into Functional Odontoblasts and Endothelium. Sakai, V. T.; Zhang, Z.; Dong, Z.; Neiva, K. G.; Machado, M. A. A. M.; Shi, S.; Santos, C. F.; N�r, J. E. // Journal of Dental Research;Aug2010, Vol. 89 Issue 8, p791 

  Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional...

• Tooth Fairy, Step Aside.  // Science Teacher;May2003, Vol. 70 Issue 5, p18 

  Reports on the results of a research showing that temporary teeth contain a rich supply of stem cells called SHED or stem cells from human exfoliated deciduous teeth, in their dental pulp. Comparison of SHED with many adult stem cells in the body; Launching of an initial round of studies to...

• Pulp Tissue from Primary Teeth: New Source of Stem Cells. Klein, William // Oral & Craniofacial Tissue Engineering;2011, Vol. 1 Issue 3, p267 

  An abstract of the study "Pulp Tissue from Primary Teeth: New Source of Stem Cells," by Paloma Dias Telles and colleagues is presented.

• Potential Characteristics of Stem Cells from Human Exfoliated Deciduous Teeth Compared with Bone Marrow--Derived Mesenchymal Stem Cells for Mineralized Tissue-Forming Cell Biology. Hompesch, Richard W. // Oral & Craniofacial Tissue Engineering;2012, Vol. 2 Issue 1, p75 

  An abstract of the article "Potential Characteristics of Stem Cells From Human Exfoliated Deciduous Teeth Compared With Bone Marrow-Derived Mesenchymal Stem Cells for Mineralized Tissue-Forming Cell Biology," by Kenji Hara et al is presented.

• Valley dentist, others, help families save stem cells. Cole, David // Journal of Business (10756124);5/7/2009, Vol. 24 Issue 10, pB3 

  The article reports on the effort of pediatric dentist Molly Gunsaulis in Spokane County, Washington, to offer families of her young patients a purpose for extracted baby teeth. According to Gunsaulis, she is offering families the opportunity to have the teeth sent to a laboratory where the stem...

• Deciduous Tooth Chronology in the Mandible of the Domestic Pig. SHELDON BIVIN, W.; MC CLURE, ROBERT C. // Journal of Dental Research;Jul1976, Vol. 55 Issue 4, p591 

  Specimens of known age, weight, and crown-rump length were used to characterize the chronology and histological development of the deciduous teeth in the right mandible of swine. Special observations were made concerning the deciduous origin of the first premolar tooth.

• Endothelial Differentiation of SHED Requires MEK1/ERK Signaling. Bento, L.W.; Zhang, Z.; Imai, A.; Nör, F.; Dong, Z.; Shi, S.; Araujo, F.B.; Nör, J.E. // Journal of Dental Research;Jan2013, Vol. 92 Issue 1, p51 

  The discovery that dental pulp stem cells are capable of differentiating into endothelial cells raises the exciting possibility that these cells can be a single source of odontoblasts and vascular networks in dental tissue engineering. The purpose of this study was to begin to define signaling...

Read the Article