TITLE

Relationship between basal metabolic rate and cortisol secretion throughout pregnancy

AUTHOR(S)
Svetozar Damjanovic; Rada Stojic; Nebojsa Lalic; Aleksandra Jotic; Djuro Macut; Sanja Ognjanovic; Milan Petakov; Bojana Popovic
PUB. DATE
April 2009
SOURCE
Endocrine (1355008X);Apr2009, Vol. 35 Issue 2, p262
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  The role of cortisol in mediating basal metabolic rate (BMR) changes that accompany the adjustment of maternal body weight (BW) and body composition during pregnancy is unknown. We tested whether increase in BMR during pregnancy is explained by variations in cortisol secretion. Longitudinal changes in BW, fat mass (FM), fat-free mass (FFM), BMR, hormonal, and metabolic parameters in 31 parous Caucasian women at gestational weeks 12, 26, and 36 were examined. Individual differences (Δ) between the last and the first measurement occasions for each variable were calculated. By gestational week 36, BW and BMR increased while both FFM/FM and BMR/BW ratio decreased (P P P P P P = 0.041), and free fatty acid (FFA) concentration (P = 0.007) increased. The elevation in BMR showed inverse correlations with ΔBW (r = 0.37, P = 0.047) and Δcortisol (r = −0.53, P = 0.004). Significant portion (51.6%) of the variation in BMR change was explained by increases of cortisol (27.1%), FFA (13.4%), and free triiodothyronine (11.1%). In conclusion, the changes in maternal cortisol concentration are in relationship with changes in BMR and BW, further suggesting that increased cortisol secretion during pregnancy could be linked with the maintenance of maternal BW and body composition.
ACCESSION #
37142361

 

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