Community-based study of the association of subclinical thyroid dysfunction with blood pressure

Yu Duan; Wen Peng; Xiaodong Wang; Wei Tang; Xiaoyun Liu; Shuhang Xu; Xiaodong Mao; Shangyong Feng; Yu Feng; Youwen Qin; Kuanfeng Xu; Cuiping Liu; Chao Liu
April 2009
Endocrine (1355008X);Apr2009, Vol. 35 Issue 2, p136
Academic Journal
Abstract  The relationship between subclinical thyroid dysfunction and blood pressure has been controversial and received unsufficient attention. Thus, we performed a cross-sectional study conducted among 6,992 inhabitants from six districts of Jiangsu Province to investigate the association of subclinical thyroid dysfunction with blood pressure in China. The data from 6,583 subjects (4,115 women and 2,468 men) were included and divided into three groups: euthyroidism (n = 5669, 86.11%), subclinical hyperthyroidism (n = 108, 1.65%), and subclinical hypothyroidism (n = 806, 12.24%). In the groups with subclinical hypothyroidism and hyperthyroidism, systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure were not significantly different from those in the groups with euthyroidism after being adjusted for age, sex, BMI, and smoking status (P > 0.05). More extensively, the SBP and DBP in the group of subclinical hypothyroidism with lower level of TSH (TSH 4.51–10.00 mIU/l, SCH1) were significantly higher than those of participants with euthyroidism (P P = 0.028). Similar results could not be found between groups of euthyroid and subclinical hypothyroid with higher level of TSH (TSH > 10 mIU/l, SCH2). Further subdivision of the euthyroid group on the basis of a TSH cut-off of 2.5 mIU/l, revealed still no significant difference in blood pressure after adjustment regardless of whether the TSH levels were in the lower reference (TSH 0.40–2.50 mIU/l, n = 4093) or in the upper reference ranges (TSH 2.51–4.50 mIU/l, n = 1576) (P > 0.05). We concluded that subclinical thyroid dysfunction was not associated with blood pressure. Neither subclinical hyperthyroidism nor subclinical hypothyroidism independently predicted increased blood pressure.


Related Articles

  • Pesticides, nickel exposure and retirement planning. Noone, Peter // Occupational Medicine;Jun2010, Vol. 60 Issue 4, p323 

    The article presents a study on the risk of thyroid disease linked with the use of herbicides, insecticides, fungicides and fumigants among female spouses of pesticide applicators in the Agricultural Health Study and their retirement plan. It conducted a cross-sectional study and analyses of...

  • VARIATION IN THYROID STATUS IN PATIENTS WITH GRAVES' ORBITOPATHY. Cozma, I.; Cozma, L. S.; Boyce, R. L.; Ludgate, M. E.; Lazarus, J. H.; Lane, C. M. // Acta Endocrinologica (1841-0987);Apr-Jun2009, Vol. 5 Issue 2, p191 

    Graves' orbitopathy usually occurs in thyrotoxic patients at the presentation of the hyperthyroidism. Aim: we conducted a cross sectional study over 8 and a half years of the relation between Graves' orbitopathy and thyroid status in patients presenting to our joint thyroidophthalmology clinic...

  • Impact of Thyroid Dysfunction on Serum Cystatin C, Serum Creatinine and Glomerular Filtration Rate. Stojanoski, Sinisa; Gjorceva, Daniela Pop; Gruev, Todor; Ristevska-Miceva, Svetlana; Ristevska, Nevena // Macedonian Journal of Medical Sciences;Apr2011, Vol. 4 Issue 1, p25 

    No abstract available.

  • The burden of hypertension in sub-Saharan Africa: a four-country cross sectional study. Guwatudde, David; Nankya-Mutyoba, Joan; Kalyesubula, Robert; Laurence, Carien; Adebamowo, Clement; Ajayi, IkeOluwapo; Bajunirwe, Francis; Njelekela, Marina; Chiwanga, Faraja S.; Reid, Todd; Volmink, Jimmy; Adami, Hans-Olov; Holmes, Michelle D.; Dalal, Shona // BMC Public Health;12/5/2015, Vol. 15 Issue 1, p1 

    Background: Hypertension, the leading single cause of morbidity and mortality worldwide, is a growing public health problem in sub-Saharan Africa (SSA). Few studies have estimated and compared the burden of hypertension across different SSA populations. We conducted a...

  • The Thyroid Status of Children and Adolescents in Fukushima Prefecture Examined during 20–30 Months after the Fukushima Nuclear Power Plant Disaster: A Cross-Sectional, Observational Study. Watanobe, Hajime; Furutani, Tomoyuki; Nihei, Masahiko; Sakuma, Yu; Yanai, Rie; Takahashi, Miyuki; Sato, Hideo; Sagawa, Fumihiko // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: A possible increase in thyroid cancer in the young represents the most critical health problem to be considered after the nuclear accident in Fukushima, Japan (March 2011), which is an important lesson from the Chernobyl disaster (April 1986). Although it was reported that childhood...

  • The HIDDEN EPIDEMIC. Uhland, Vicky // Natural Solutions;Mar2010, Issue 123, p56 

    The article focuses on the epidemic of having thyroid disease in the U.S. According to the American Association of Clinical Endocrinologist (AACE), 27 millions Americans are unaware that they have thyroid disease since doctors are often confused with the symptoms of the thyroid disease which is...

  • Prevalence of thyroid dysfunction and its correlation with CD4 count in newly-diagnosed HIV-positive adults--a cross-sectional study. Dev, Nishanth; Sahoo, Ratnakar; Kulshreshtha, Bindu; Gadpayle, A. K.; Sharma, S. C. // International Journal of STD & AIDS;Nov2015, Vol. 26 Issue 13, p965 

    Prevalence of subclinical hypothyroidism in HIV-positive patients is reported to be high in those with severe immune deficiency. However, there is paucity of literature in newly-diagnosed HIV-positive population. Our aim was to estimate the prevalence of thyroid dysfunction and study its...

  • Evaluation of Dennal Symptoms in Hypothyroidism and Hyperthyroidism. Razi, Ahad; Golforoushan, Farideh; Babaee Nejad, Amir Bahrami Shahla; Goldust, Mohamad // Pakistan Journal of Biological Sciences;2013, Vol. 16 Issue 11, p541 

    Many symptoms arise in thyroid diseases. The aim of this study was to evaluate the dermal symptoms in hypothyroidism and hyperthyroidism. In this cross sectional study, 120 patients with hyperthyroidism and 50 patients suffering from hypothyroidism were studied. Cutaneous, hair and nail...

  • Cross sectional evaluation of thyroid hormone levels in non-diabetic and diabetic patients in Bangladeshi population. Jahangir Alam, Md.; Mokarrama Mukti, Most Nur-E.-Taj; Mominul Hoque, Md.; Intaz Ali, Md.; Mallik, Sunil C.; Mostafa Kamal, Md.; Choudhury, Subhagata // Journal of Advanced Medical Research;Jun2013, Vol. 3 Issue 2, p25 

    Diabetes mellitus (DM) and thyroid dysfunction are the common disorders in human being and diabetes mellitus in many cases is found to be associated with disordered thyroid function. This evaluation study was conducted at the Z. H Sikder Women's Medical Collage and Hospital (Pvt) Ltd., Gulshan...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics