TITLE

c-Jun N-terminal kinases inhibitor suppresses the TNF-α induced MCP-1 expression in human umbilical vein endothelial cells

AUTHOR(S)
Rania Ahmed; Koji Murao; Hitomi Imachi; Kazuya Yoshida; Hiroaki Dobashi; Naohisa Hosomi; Toshihiko Ishida
PUB. DATE
April 2009
SOURCE
Endocrine (1355008X);Apr2009, Vol. 35 Issue 2, p184
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine that is considered to be an important chemotactic factor for monocytes. MCP-1 is expressed in the macrophage-rich areas of atherosclerotic lesions. A recent report indicated that MCP-1 expression in human umbilical vein endothelial cells (HUVECs) is induced by the stimulation of tumor necrosis factor (TNF)-α via the c-Jun N-terminal kinases (JNK) pathway. In this study, we examined the effects of JNK inhibitor (JNKI-1), on MCP-1 expression. The results of this study indicated that the expression of MCP-1 mRNA and protein were stimulated in the presence of TNF-α. TNF-α stimulated the phosphrylation of JNK, however, JNKI-1 inhibited the TNF-α stimulated MCP-1 secretion and gene expression. As expected, JNKI-1 blocked the stimulatory effect of TNF-α on the MCP-1 promoter activity. In conclusion, JNKI-1 partially inhibits the TNF-α-induced MCP-1 expression in HUVECs, and therefore JNKI-1 may be of therapeutic value in the treatment of diseases such as atherosclerosis.
ACCESSION #
37142355

 

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