TITLE

Influence of Platelet-rich Plasma on Bone Regeneration: A Histomorphometric Study in Rabbit Calvaria

AUTHOR(S)
Torres, Jesús; Tresguerres, Isabel; Tamimi, Faleh; Clemente, Celia; Niembro, Enrique; Blanco, Luis
PUB. DATE
July 2007
SOURCE
International Journal of Oral & Maxillofacial Implants;Jul/Aug2007, Vol. 22 Issue 4, p563
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: The aim of this study was to evaluate whether local application of platelet-rich plasma (PRP) would induce bone regeneration in cranial defects on rabbits. Materials and Methods: Twelve female New Zealand rabbits were used for this study. Two identical 10-mm-diameter bicortical cranial defects were created in each animal. One of the defects was grafted with PRP, while the contralateral was left unfilled as a negative control. Animals were sacrificed at 2, 4, 6, and 8 weeks after surgery, and biopsy specimens were evaluated histologically and histomorphometrically under light microscopy. Analysis of variance was used for statistical analysis. Results: The histomorphometric evaluation showed more regenerated bone after local administration of PRP at 2 weeks (P > .05), 4 weeks (P < .05), and 6 weeks (P > .05). At week 8, new bone formation was comparable in both groups. Conclusion: In this animal model, local application of PRP in bone defects enhances healing significantly at 4 weeks.
ACCESSION #
36967251

 

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