TITLE

The effect of joint exposures: examining the presence of interaction

AUTHOR(S)
de Mutsert, Renée; Jager, Kitty J; Zoccali, Carmine; Dekker, Friedo W
PUB. DATE
April 2009
SOURCE
Kidney International;Apr2009, Vol. 75 Issue 7, p677
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Clinical epidemiological studies investigate whether an exposure, or risk factor, is causally related to the development or progression of a disease or mortality. It might be of interest to study whether this relation is different in different types of patients. To address such research questions, the presence of interaction among risk factors can be examined. Causal interaction between two risk factors is considered most clinically relevant in epidemiology. Causal interaction occurs when two risk factors act together in causing disease and is explicitly defined as a deviation from additivity on a risk difference scale. Statistical interaction can be evaluated on both an additive (absolute risk) and multiplicative (relative risk) scale, depending on the model that is used. When using logistic regression models, which are multiplicative models, several measures of additive interaction are presented to evaluate whether the magnitude of an association differs across subgroups: the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP), or the synergy index (S). For a transparent presentation of interaction effects the recent Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement advises reporting the separate effect of each exposure as well as the joint effect compared with the unexposed group as a joint reference category to permit evaluation of both additive and multiplicative interaction.Kidney International (2009) 75, 677–681; doi:10.1038/ki.2008.645; published online 4 February 2009
ACCESSION #
36893246

 

Related Articles

  • Estimating the Relative Risk in Cohort Studies and Clinical Trials of Common Outcomes. L-A. McNutt; C. Wu; X. Xue; J.P. Hafner // American Journal of Epidemiology;5/15/2003, Vol. 157 Issue 10, p940 

    Logistic regression yields an adjusted odds ratio that approximates the adjusted relative risk when disease incidence is rare (<10%), while adjusting for potential confounders. For more common outcomes, the odds ratio always overstates the relative risk, sometimes dramatically. The purpose of...

  • Individual and community risk factors and sexually transmitted diseases among arrested youths: a two level analysis. Dembo, Richard; Belenko, Steven; Childs, Kristina; Wareham, Jennifer; Schmeidler, James // Journal of Behavioral Medicine;Aug2009, Vol. 32 Issue 4, p303 

    High rates of infection for chlamydia and gonorrhea have been noted among youths involved in the juvenile justice system. Although both individual and community-level factors have been found to be associated with sexually transmitted disease (STD) risk, their relative importance has not been...

  • Cardiorespiratory fitness predicts clustered cardiometabolic risk in 10-11.9-year-olds. Houston, Emma; Baker, Julien; Buchan, Duncan; Stratton, Gareth; Fairclough, Stuart; Foweather, Lawrence; Gobbi, Rebecca; Graves, Lee; Hopkins, Nicola; Boddy, Lynne // European Journal of Pediatrics;Jul2013, Vol. 172 Issue 7, p913 

    The aim of this study was to investigate levels of clustered cardiometabolic risk and the odds of being 'at risk' according to cardiorespiratory fitness status in children. Data from 88 10-11.9-year-old children (mean age 11.05 ± 0.51 years), who participated in either the REACH Year 6 or the...

  • Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications. Liang, Chih-Chia; Muo, Chih-Hsin; Wang, I-Kuan; Chang, Chiz-Tzung; Chou, Che-Yi; Liu, Jiung-Hsiun; Yen, Tzung-Hai; Huang, Chiu-Ching; Chung, Chi-Jung // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Objectives: We aimed at determining peptic ulcer disease (PUD) incidence among chronic kidney disease (CKD) patients during 1998–2008, compared to patients without CKD, and at examining associations between CKD and PUD. Methods: Data for 1998–2008 were extracted from the National...

  • A simple model for predicting incidence of chronic kidney disease in HIV-infected patients. Ando, Minoru; Yanagisawa, Naoki; Ajisawa, Atsushi; Tsuchiya, Ken; Nitta, Kosaku // Clinical & Experimental Nephrology;Apr2011, Vol. 15 Issue 2, p242 

    Background: Human immunodeficiency virus (HIV)-infected individuals have concurrent risk factors for chronic kidney disease (CKD), but there are no prediction models to quantify the effect of multiple factors on the development of incident CKD. Methods: A 1-year prognostic model was developed...

  • Derivation and validation of a risk score for contrast-induced nephropathy after cardiac catheterization in Chinese patients. Gao, Yu-mei; Li, Di; Cheng, Hong; Chen, Yi-pu // Clinical & Experimental Nephrology;Dec2014, Vol. 18 Issue 6, p892 

    Background: To derive and validate a risk score for prediction of contrast-induced nephropathy (CIN) in the Chinese patients undergoing cardiac catheterization. Methods: The hospital medical records of 3945 patients undergoing coronary angiography or percutaneous coronary intervention were...

  • Circulating Adipocytokines and Chronic Kidney Disease. Mills, Katherine T.; Hamm, L. Lee; Alper, A. Brent; Miller, Chad; Hudaihed, Alhakam; Balamuthusamy, Saravanan; Chen, Chung-Shiuan; Liu, Yanxi; Tarsia, Joseph; Rifai, Nader; Kleinpeter, Myra; He, Jiang; Chen, Jing // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Background: Adipokines have been associated with atherosclerotic heart disease, which shares many common risk factors with chronic kidney disease (CKD), but their relationship with CKD has not been well characterized. Methods: We investigated the association of plasma leptin, resistin and...

  • Risk Factors for Contrast-related Acute Kidney Injury According to Risk, Injury, Failure, Loss, and End-stage Criteria in Patients With Coronary Interventions. Pakfetrat, Maryam; Nikoo, Mohammad Hossein; Malekmakan, Leila; Tabande, Mahmood; Roozbeh, Jamshid; Reisjalali, Ganbarali; Zare, Najaf; Khajedehi, Parviz // Iranian Journal of Kidney Diseases;Apr2010, Vol. 4 Issue 2, p116 

    Introduction. Although a series of risk factors for contrast-induced nephropathy are known, data on significance of some of the risk factors such as age, sex, hypercholesterolemia, hyperuricemia, and dose of contrast medium are inconsistent. Our aim was to identify risk factors for...

  • Factors associated with severe maternal morbidity and near miss in the São Francisco Valley, Brazil: a retrospective, cohort study. Correia Pacheco, Alvaro José; Katz, Leila; Souza, Alex Sandro Rolland; de Amorim, Melania Maria Ramos // BMC Pregnancy & Childbirth;2014, Vol. 14 Issue 1, p1 

    Background Maternal mortality remains a major public health issue worldwide, with persistent high rates prevailing principally in underdeveloped countries. The objective of this study was to determine the risk factors for severe maternal morbidity and near miss (SMM/NM) in pregnant and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics