TITLE

Intolerant of glucose and gasping for oxygen

AUTHOR(S)
Gribble, Fiona M.
PUB. DATE
March 2009
SOURCE
Nature Medicine;Mar2009, Vol. 15 Issue 3, p247
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the studies regarding the effects of hypoxia inducible transcription factor (HIF) pathway activation in insulin-producing beat cells in the pancreas. Results show that HIF activation leads to the impairment of adenosine triphosphate (ATP), reduced insulin secretion and whole-body glucose intolerance. Furthermore, defective insulin secretion observed in people with type 2 diabetes may be contributed by HIF activation.
ACCESSION #
36818278

 

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