TITLE

When integrins fail to integrate

AUTHOR(S)
Hidalgo, Andrés; Frenette, Paul S.
PUB. DATE
March 2009
SOURCE
Nature Medicine;Mar2009, Vol. 15 Issue 3, p249
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on the effects when integrins are inactivated due to several naturally occurring mutations. It notes that integrins can rapidly make blood cells and ensure normal blood flow. It states that integrins mediate rapid formation of a platelet plug after vessel injury. However, when integrins are inactivated, it can lead to Glanzmann's thrombasthenia, characterized by continuous bleeding. Moreover, the causes to leukocyte adhesion deficiency III (LAD-III) are discussed.
ACCESSION #
36818273

 

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