Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

Jie Sun; Madan, Rajat; Karp, Christopher L.; Braciale, Thomas J.
March 2009
Nature Medicine;Mar2009, Vol. 15 Issue 3, p277
Academic Journal
Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8+ and CD4+ effector T cells (Teff cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts—exclusively by infiltrating virus-specific Teff cells, with CD8+ Teff cells contributing a larger fraction of the IL-10 produced. These Teff cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the Teff cell–derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral Teff cells exert regulatory functions—that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses.


Related Articles

  • T cell-dependent production of IFN-γ by NK cells in response to influenza A virus. Xiao-Song He; Draghi, Monia; Mahmood, Kutubuddin; Holmes, Tyson H.; Kemble, George W.; Dekker, Cornelia L.; Arvin, Ann M.; Parham, Peter; Greenberg, Harry B. // Journal of Clinical Investigation;Dec2004, Vol. 114 Issue 12, p1812 

    The role of human NK cells in viral infections is poorly understood. We used a cytokine flow-cytometry assay to simultaneously investigate the IFN-γ response of NK and T lymphocytes to influenza A virus (fluA). When PBMCs from fluA-immune adult donors were incubated with fluA, IFN-γ was...

  • Nasal Cytokine and Chemokine Responses in Experimental Influenza A Virus Infection: Results of a... Fritz, R. Scott; Hayden, Frederick G.; Calfee, David P.; Cass, Lindsey M.R.; Peng, Amy W.; Alvord, W. Gregory; Strober, Warren; Straus, Stephen E. // Journal of Infectious Diseases;9/1/99, Vol. 180 Issue 3, p586 

    Characterizes the local immune response to influenza virus infection through the determination of cytokine and chemokine levels in serial nasal lavate fluid samples from volunteers experimentally infected with influenza A. Effect of the inhibitor zanamivir on the clinical symptoms of influenza...

  • Th2 Responses to Inactivated Influenza Virus Can Be Converted to Th1 Responses and Facilitate... Moran, Thomas M.; Park, Helen; Fernandez-Sesma, Ana; Schulman, Jerome L. // Journal of Infectious Diseases;9/1/99, Vol. 180 Issue 3, p579 

    Reports on the conversion of Th2 memory cell responses to inactivated influenza virus to Th1 responses for recovery facilitation from heterosubtypic virus infection. Process used for the conversion; Mechanism by which inactivated virus immunization mediates heterosubtypic immunity.

  • Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function. Yuet Wu; Huawei Mao; Man-To Ling; Kin-Hung Chow; Pak-Leung Ho; Wenwei Tu; Yu-Lung Lau // BMC Infectious Diseases;2011, Vol. 11 Issue 1, p201 

    Background: Influenza virus is a major cause of respiratory disease worldwide and Streptococcus pneumoniae infection associated with influenza often leads to severe complications. Dendritic cells are key antigen presenting cells but its role in such co-infection is unclear. Methods: In this...

  • Analysis of cytokine production in a newly developed canine tracheal epithelial cell line infected with H3N2 canine influenza virus. Park, Woo-Jung; Park, Byung-Joo; Song, Young-Jo; Lee, Dong-Hun; Yuk, Seong-Su; Lee, Joong-Bok; Park, Seung-Yong; Song, Chang-Seon; Lee, Sang-Won; Choi, In-Soo // Archives of Virology;Jun2015, Vol. 160 Issue 6, p1397 

    The Madin-Darby canine kidney (MDCK) cell line is typically used to analyze pathological features after canine influenza virus (CIV) infection. However, MDCK cells are not the ideal cell type, because they are kidney epithelial cells. Therefore, we generated an immortalized canine tracheal...

  • Role of Memory T Cells in Influenza Viral Infection. Halwani, Rabih; Doroudchi, Mehrnoosh; El-Far, Mohamed; Tanel, Andre; Yu Shi; Yassine-Diab, Bader; S�kaly, Rafick-Pierre // Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry;Jun2008, Vol. 7 Issue 2, p87 

    The major role of memory T cells is to ensure protection upon re-exposure to pathogens through rapid clonal proliferation and functional activation. This immunity usually persists for periods which can extend for over 60 years. These memory T cells are generated during acute viral infections. In...

  • Exploring Cell Tropism as a Possible Contributor to Influenza Infection Severity. Dobrovolny, Hana M.; Baron, Marc J.; Gieschke, Ronald; Davies, Brian E.; Jumbe, Nelson L.; Beauchemin, Catherine A. A. // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Several mechanisms have been proposed to account for the marked increase in severity of human infections with avian compared to human influenza strains, including increased cytokine expression, poor immune response, and differences in target cell receptor affinity. Here, the potential effect of...

  • Avian influenza, China.  // Weekly Epidemiological Record;1/13/2006, Vol. 81 Issue 2, p13 

    The article presents news related to the spread of Avian influenza in China. Chinese officials detected the eighth case of human infection with the H5N1 avian influenza virus. Preliminary investigation of the newly found case has identified recent poultry deaths in the family flock as the likely...

  • TEpredict: Software for T-Cell epitope prediction. Antonets, D. V.; Maksyutov, A. Z. // Molecular Biology;Feb2010, Vol. 44 Issue 1, p119 

    The program TEpredict was developed for T-cell epitope prediction. The used models for T-cell epitope prediction were constructed by the partial least squares regression method using the data extracted from the IEDB (Immune Epitope Database), the most complete resource of experimental...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics