TITLE

Estimation of the Relative Excess Risk Due to Interaction and Associated Confidence Bounds

AUTHOR(S)
David B. Richardson; Jay S. Kaufman
PUB. DATE
March 2009
SOURCE
American Journal of Epidemiology;Mar2009, Vol. 169 Issue 6, p756
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The relative excess risk due to interaction (RERI) provides a useful metric of departure from additivity of effects on a relative risk scale. In this paper, the authors show that RERI is identical to the product term in a linear odds ratio or a linear relative risk model. SAS and STATA codes are provided for fitting a linear odds ratio model that directly parameterizes RERI. In addition, this paper presents a method for obtaining likelihood-based 95% confidence bound estimates for RERI. The authors show that likelihood-based confidence intervals may differ substantially from the asymptotic confidence interval estimates advocated by previous authors. The approach presented in this paper should facilitate estimation of RERI and associated likelihood-based confidence bounds, by using standard statistical packages.
ACCESSION #
36783828

 

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