Radon Exposure and Mortality Among White and American Indian Uranium Miners: An Update of the Colorado Plateau Cohort

Mary K. Schubauer-Berigan; Robert D. Daniels; Lynne E. Pinkerton
March 2009
American Journal of Epidemiology;Mar2009, Vol. 169 Issue 6, p718
Academic Journal
Studies of uranium miners on the US Colorado Plateau have identified associations between exposure to radon progeny and risk of lung cancer. This study added 15 years of mortality follow-up for the 4,137 miners (primarily white or American Indian) in the Colorado Plateau cohort. The cohort experienced 209 new lung cancer deaths. For white miners, the standardized mortality ratio for lung cancer compared with the regional population was 3.99 (95% confidence interval: 3.43, 4.62) for the period 1991–2005. For American Indian miners, the lung cancer standardized mortality ratio was 3.27 (95% confidence interval: 2.19, 4.73). These standardized mortality ratios have not declined substantially since the 1980s. Internally standardized rate ratios by radon exposure category over the entire follow-up period are similar to those based on earlier follow-up, although estimates within smoking categories demonstrated improved precision. The apparent interaction between radon and smoking in causing lung cancer remains submultiplicative but greater than additive. Mortality rates from silicosis remain highly elevated in the cohort. Elevated mortality rates were observed from interstitial pulmonary fibrosis, multiple myeloma, and non-Hodgkin lymphoma. Significant trends were observed with increased radon exposure in silicosis and pulmonary fibrosis mortality and in the incidence of diabetes-related end-stage renal disease among white miners.


Related Articles

  • Cohort Profile: The German uranium miners cohort study (WISMUT cohort), 1946–2003. Kreuzer, Michaela; Schnelzer, Maria; Tschense, Annemarie; Walsh, Linda; Grosche, Bernd // International Journal of Epidemiology;Aug2010, Vol. 39 Issue 4, p980 

    The article discusses a study on the detrimental effects of radon and uranium inhalation and gamma radiation exposure on German uranium miners from 1946 to 2003. According to the study, individual information on year of birth, vital status, mortality, job history and exposure was collected, and...

  • AIR RADON CONCENTRATION DECREASE IN A WASTE WATER TREATMENT PLANT. Juste, B.; Ortiz, J.; Verdú, G.; Martorell, S. // Radiation Protection Dosimetry;2015 Special Issue, Vol. 164, p497 

    222Rn is a naturally occurring gas created from the decay of 226Ra. The long-term health risk of breathing radon is lung cancer. One particular place where indoor radon concentrations can exceed national guidelines is in wastewater treatment plants (WWTPs) where treatment processes may...

  • Biophysical modelling of the effects of inhaled radon progeny on the bronchial epithelium for the estimation of the relationships applied in the two-stage clonal expansion model of carcinogenesis. Madas, Balázs G.; Varga, Katalin // Radiation Protection Dosimetry;Jun2014, Vol. 159 Issue 1-4, p237 

    There is a considerable debate between research groups applying the two-stage clonal expansion model for lung cancer risk estimation, whether radon exposure affects initiation and transformation or promotion. The aim of the present study is to quantify the effects of radon progeny on these...

  • RADON EXHALATION FROM SUB-SLAB AGGREGATE USED IN HOME CONSTRUCTION IN CANADA. Bergman, Lauren; Jaeyoung Lee; Baki Sadi; Jing Chen // Radiation Protection Dosimetry;2015 Special Issue, Vol. 164, p606 

    Exposure to elevated levels of radon in homes has been shown to result in an increased risk of developing lung cancer. The two largest contributors to indoor radon are radon in soil gas, formed from the rocks and soil surrounding the home, and building materials such as aggregate. This study...

  • Differences in baseline lung cancer mortality between the German uranium miners cohort and the population of the former German Democratic Republic (1960-2003). Walsh, Linda; Dufey, Florian; Möhner, Matthias; Schnelzer, Maria; Tschense, Annemarie; Kreuzer, Michaela // Radiation & Environmental Biophysics;Mar2011, Vol. 50 Issue 1, p57 

    previous analysis of the radon-related lung cancer mortality risk, in the German uranium miners cohort, using Poisson modeling techniques, noted internal (spontaneous) rates that were higher on average than the external rates by 16.5% (95% CI: 9%; 24%). The main purpose of the present paper is...

  • Deadly Radon in Montana? Puskin, Jerome S. // Dose-Response;2011, Vol. 9 Issue 3, p442 

    No abstract available.

  • Diesel motor exhaust and lung cancer mortality: reanalysis of a cohort study in potash miners. Möhner, Matthias; Kersten, Norbert; Gellissen, Johannes // European Journal of Epidemiology;Feb2013, Vol. 28 Issue 2, p159 

    The aim of the reanalysis is to reassess lung cancer risk associated with occupational exposure to diesel motor exhaust in potash miners, while controlling for potential confounders such as smoking and previous occupational history. Our investigation is based on a cohort study of nearly 6,000...

  • Individualized Risk Prediction Model for Lung Cancer in Korean Men. Park, Sohee; Nam, Byung-Ho; Yang, Hye-Ryung; Lee, Ji An; Lim, Hyunsun; Han, Jun Tae; Park, Il Su; Shin, Hai-Rim; Lee, Jin Soo // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Purpose: Lung cancer is the leading cause of cancer deaths in Korea. The objective of the present study was to develop an individualized risk prediction model for lung cancer in Korean men using population-based cohort data. Methods: From a population-based cohort study of 1,324,804...

  • Re: Indoor radon exposure and risk of lung cancer: A nested case-control study in Finland. Lagarde, Frederic; Pershagen, Goran // JNCI: Journal of the National Cancer Institute;04/16/97, Vol. 89 Issue 8, p584 

    Details the findings of an epidemiologic study on residential radon exposure and lung cancer in Finland. Causes and risks of lung cancer; Questions raised concerning the validity of reported risk estimates for residential radon in relation to control for tobacco smoking.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics