TITLE

Direct optical detection in fragment-based screening

AUTHOR(S)
Pröll, Florian; Fechner, Peter; Proll, Günther
PUB. DATE
March 2009
SOURCE
Analytical & Bioanalytical Chemistry;Mar2009, Vol. 393 Issue 6/7, p1557
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Label-free biosensors based on direct optical detection principles are widely used in many different fields of research. Currently the higher level of automation and the increasing throughput of this technology are stimulating the interest of pharmaceutical companies. The information gained with label-free biosensors can be extremely valuable during the drug design process, particularly in combination with complementary techniques, including NMR, mass spectrometry and X-ray crystallography. In this article we focus on the advantages of direct optical biosensors especially in the field of fragment-based drug design, which is a widely used and extremely promising concept. Furthermore, we present optical biosensors as versatile tools for fragment-based screening and the future drug design process.
ACCESSION #
36778873

 

Related Articles

  • Characterization of sensing capability of optofluidic ring resonator biosensors. Hao Li; Xudong Fan // Applied Physics Letters;7/5/2010, Vol. 97 Issue 1, p011105 

    The sensing capability of the capillary-based optofluidic ring resonator in bulk refractive index (RI) detection and label-free small molecule detection is investigated. In bulk RI detection, a sensitivity of 570 nm/refractive index units (RIU) is achieved with a Q-factor of 1.2×105. A...

  • Optical biosensors in drug discovery. Cooper, Matthew A. // Nature Reviews Drug Discovery;Jul2002, Vol. 1 Issue 7, p515 

    Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors have been used widely over the past decade to analyse biomolecular interactions. These sensors allow the determination of the affinity and kinetics of a wide variety of molecular interactions in real time,...

  • Label-free Acoustic and Optical Biosensors Playing on Evanescent Waves. Yihui Wu; Guigen Liu; Peng Hao; Junfeng Wu; Yongbo Deng; Yongshun Liu; Ming Xuan // PIERS Proceedings;Aug2013, p1756 

    Development of sensitive, reliable, high-throughput, label-free detection techniques is an issue with increasing emphasis because the labeling strategies that most of the microarray applications have employed, such as fluorescent, chemiluminescent and radioactive labeling, have synthetic...

  • Label-Enhanced Surface Plasmon Resonance: A New Concept for Improved Performance in Optical Biosensor Analysis. Granqvist, Niko; Hanning, Anders; Eng, Lars; Tuppurainen, Jussi; Viitala, Tapani // Sensors (14248220);Nov2013, Vol. 13 Issue 11, p15348 

    Surface plasmon resonance (SPR) is a well-established optical biosensor technology with many proven applications in the study of molecular interactions as well as in surface and material science. SPR is usually applied in the label-free mode which may be advantageous in cases where the presence...

  • Tilted FBGs excite optical-fiber plasmons. Albert, Jacques; Shevchenko, Yanina // Laser Focus World;Jan2010, Vol. 46 Issue 1, p71 

    The article discusses the development of the surface plasmon resonance (SPR) technique that detects chemical and biochemical changes that occur between molecules. The technique is a plasmon-based detector created from a standard single-mode optical fiber and uses tilted fiber Bragg gratings and...

  • State-of-the-Art of (Bio)Chemical Sensor Developments in Analytical Spanish Groups. Plata, María Reyes; Contento, Ana María; Ríos, Angel // Sensors (14248220);2010, Vol. 10 Issue 4, p2511 

    (Bio)chemical sensors are one of the most exciting fields in analytical chemistry today. The development of these analytical devices simplifies and miniaturizes the whole analytical process. Although the initial expectation of the massive incorporation of sensors in routine analytical work has...

  • Sensitivity Enhancement of Biochemical Sensors Based on Er+3 Doped Microsphere Coupled to an External Mirror. Bahrampour, Alireza; Azhir, Azam Gholampour; Taghiabadi, Razie; Yazdi, kazem Rahimi // Sensors & Transducers (1726-5479);Sep2010, Vol. 120 Issue 9, p152 

    In this paper we proposed an active optical sensor designed based on the Er+3 -doped microsphere coupled to an external mirror. The microsphere-mirror coupling causes the degeneracy splitting of the resonance frequencies. Each of resonance frequencies splits in to two different resonance...

  • Europt(r)ode X : Tenth European conference on optical chemical sensors and biosensors. Krieg, A. Katrin; Furin, Dominik; Albrecht, Christiane; Kolarov, Felix; Ewald, Melanie // Analytical & Bioanalytical Chemistry;Nov2010, Vol. 398 Issue 5, p1863 

    The article discusses highlights of the Europt(r)ode X Conference in Prague, the Czech Republic from March 28-31, 2010. The conference on optochemical sensing and biosensing was attended by 244 delegates from 25 countries. Presentations were made on integrated optical systems, micro, nano and...

  • The physics of extreme sensitivity in whispering gallery mode optical biosensors. Lopez-Yglesias, Xerxes; Gamba, Jason M.; Flagan, Richard C. // Journal of Applied Physics;Apr2012, Vol. 111 Issue 8, p084701 

    Whispering gallery mode (WGM) optical biosensors are capable of extraordinarily sensitive specific and nonspecific detection of species suspended in a gas or fluid. Recent experimental results suggest that these devices may attain single-molecule sensitivity to protein solutions in the form of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics