TITLE

Efficacy of ER-α Polymorphisms and the Intrafollicular IGF System for Predicting Pregnancy in IVF-ET Patients

AUTHOR(S)
Young Sik Choi; Seok Hyun Kim; Seung-Yup Ku; Byung Chul Jee; Chang Suk Suh; Young Min Choi; Jung Gu Kim; Shin Yong Moon
PUB. DATE
February 2009
SOURCE
Gynecologic & Obstetric Investigation;Feb2009, Vol. 67 Issue 2, p73
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims: To evaluate the efficacies of the estrogen receptor-α (ER-α) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. Methods: A total of 96 patients undergoing IVF-ET were included in this study. Genotyping for the ER-α gene PvuII and XbaI polymorphisms was performed using polymerase-chain reaction and single base extension method. Follicular fluid (FF) IGF-I, IGF-II, and IGFBP-3 concentrations were measured by RIA, and IGFBP-4 by ELISA. We compared, between pregnant (n = 28) and non-pregnant groups (n = 68), the allele frequency, genotype distribution and haplotype distribution of PvuII and XbaI polymorphisms, and then FF IGF-I, IGF-II, IGFBP-3, IGFBP-4 concentrations and their ratios. Results: No significant differences were found between the two groups in terms of allele, genotype or haplotype distributions of the ER-α gene PvuII and XbaI polymorphisms between the two groups. The mean FF IGF-I/IGFBP-3 ratio was significantly higher in the pregnant group (5.9 ± 1.5 vs. 4.8 ± 1.5 ×10–2). Conclusions: The intrafollicular IGF-I/IGFBP-3 ratio of the FF of the dominant follicle during oocyte retrieval appears to be related to the establishment of pregnancy in IVF-ET patients, whereas the ER-α gene PvuII and XbaI polymorphisms do not. Copyright © 2008 S. Karger AG, Basel
ACCESSION #
36684758

 

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