Effects of Fibrin Glue on Lymphatic Drainage after Modified Radical Mastectomy: A Prospective Randomized Trial

Dinsmore, Robert C.; Harris, James A.; Gustafson, Robert J.
October 2000
American Surgeon;Oct2000, Vol. 66 Issue 10, p982
Academic Journal
Fibrin as a tissue sealant has been used since the turn of the century for hemostasis. The development of cryoprecipitate and the resultant availability of higher concentrations of fibrinogen have led to a resurgence of interest in this material. Fibrin glue has since been shown to be effective for numerous applications throughout the field of surgery. Animal studies have shown fibrin glue to be effective at reducing drain output after mastectomy. Human studies, however, have been equivocal. Our objectives were to determine whether the use of fibrin glue would decrease lymphatic drainage after modified radical mastectomy and subsequently reduce time to drain removal. A prospective randomized trial was conducted consisting of 27 women. All women received modified radical mastectomy. At the completion of the mastectomy they were randomized to receive either standard closure or the application of fibrin glue before standard closure. Patients were then monitored for daily drain output, time to drain removal, and wound complications. A total of 14 women received fibrin glue and 13 received no glue. Those patients receiving fibrin glue had a significantly higher average drain output than patients who did not receive glue (1308 vs 754 cm[sup 3]; P = 0.012). Time to drain removal was also increased by 4 days, although this did not reach statistical significance. The overall complication rate was higher for the fibrin glue group, although again, this did not reach significance. The application of fibrin glue significantly increased drain total drain output after modified radical mastectomy. Time to drain removal was increased as was the complication rate. On the basis of these data fibrin glue cannot be recommended for routine use in modified radical mastectomy.


Related Articles

  • Fibrin Sealant (Evicel® [Quixil®/Crossealâ„¢]): A Review of its Use as Supportive Treatment for Haemostasis in Surgery. Dhillon, Sohita // Drugs;2011, Vol. 71 Issue 14, p1893 

    Evicel® is a fibrin sealant consisting of two components, human clottable protein (predominantly human fibrinogen) and human thrombin. It is indicated as supportive treatment in patients undergoing surgery when control of bleeding by standard surgical techniques is ineffective or impractical....

  • Reinforcement of an end-to-end tracheal resection anastomosis with fibrin glue: A case report. Kacker, Ashutosh; Huo, Jerry // ENT: Ear, Nose & Throat Journal;Apr2001, Vol. 80 Issue 4, p234 

    Tracheal resection and primary anastomosis is the treatment of choice for a short-segment stenosis. However, the procedure does carry the risk of two potentially fatal complications: anastomosis breakdown and leak. We describe the case of a 67-year-old man who was treated for a 3-cm tracheal...

  • CROHN'S DISEASE.  // Current Medical Literature: Gastroenterology;2005, Vol. 24 Issue 4, p84 

    The section presents the results of several studies on Crohn's disease. The topics include novel therapies for inflammatory bowel disease, the risk of relapse in Crohn's disease patients in long-term remission on azathioprine and the long-term healing of Crohn's anal fistulas with fibrin glue...

  • Closure of Proximal Colorectal Fistulas Using Fibrin Sealant. Lamont, Jeffrey P.; Hooker, Glen; Espenschied, Jonathan R.; Lichliter, Warren E.; Franko, Edward // American Surgeon;Jul2002, Vol. 68 Issue 7, p615 

    Fibrin glue has been used in upper gastrointestinal and perianal fistula disease, but its success in proximal colorectal pathology has not been widely documented. This report describes the use of endoscopically injected fibrin glue as a successful adjunct to traditional methods in accelerating...

  • The effect of sealing with a fixed combination of collagen matrix-bound coagulation factors on the healing of colonic anastomoses in experimental high-risk mice models. Pantelis, Dimitrios; Beissel, Anke; Kahl, Philip; Wehner, Sven; Vilz, Tim O.; Kalff, Joerg C. // Langenbeck's Archives of Surgery;Nov2010, Vol. 395 Issue 8, p1039 

    Purpose: Experimental and clinical studies on the sealing of colorectal anastomoses in order to reduce the rate of leakage have previously been performed with divergent results. However, comparatively few studies have been performed on anastomotic healing using a fibrin glue-coated patch. The...

  • Fibrin glue may be used to close some fistulas. Overmyer, Mac // Urology Times;Jul2001, Vol. 29 Issue 7, p27 

    Reports on the use of fibrin glue to close urinary tract fistulas as of July 2001. Background on the study presented by Maywood, Illinois-based Loyola University Medical Center urology professor Thomas Turk during the American Urological Association's year 2001 meeting in Anaheim, California.

  • Comparative Study between Fibrin Glue and Surgical Treatment of Pilonidal Sinus. El-Sayed Ahmed Mostafa; Mahmoud Abdalla Abd-Elrazik; Zahraa Futtoh Mohammed; Mohamed Mahmoud Gharieb // Egyptian Journal of Hospital Medicine;4/11/2019, Vol. 75 Issue 6, p3107 

    Background: Published results have shown that fibrin glue may be effective in closure of pilonidal fistula. We report the final results of a randomized clinical trial evaluating the use of fibrin glue in treatment of pilonidal fistula. Objectives: to determine the efficacy of a new simple with...

  • Development of a Model for Measurement of Adhesion Strength of Fibrin Sealant to Human Tissue. Velada, J.L.; Pulawska, T.; Ellensen, V.S.; Larsen, S.S.; Hollingsbee, D.A.; Kjaergard, H.K. // European Surgical Research;1999, Vol. 31 Issue 6, p491 

    It is crucial for the surgeon to know the physical properties of a surgical sealant. Current test methods of fibrin sealant involving animal testing or in vitro testing of sealant using artificial substrates have little clinical relevance. Most of these test methods also lack accuracy and...

  • Percutaneous sclerotherapy of massive macrocystic lymphatic malformations of the head and neck using fibrin glue with OK-432 and bleomycin. ZHOU Miao; HUANG Zhi-quan; CHAI Qiang; CHEN Wei-Hang // China Journal of Oral & Maxillofacial Surgery;Sep2012, Vol. 10 Issue 5, p432 

    PURPOSE: Picibanil (OK-432) and bleomycin have been used as alternative sclerosing agents for lymphatic malformations. The purpose of the study is to evaluate the clinical curative effect of sclerotherapy using fibrin glue combined with OK-432 and bleomycin for the treatment of macrocystic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics