TITLE

Temporal Dynamics of a Predominant Protease Inhibitor-Resistance Mutation in a Treatment-Naive, Hepatitis C Virus-Infected Individual

AUTHOR(S)
Kim, Arthur Y.; Joerg Timm; Nolan, Brian E.; Reyor, Laura L.; Kane, Katherine; Berical, Andrew C.; Zachary, Kimon C.; Lauer, Georg M.; Kuntzen, Thomas; Allen, Todd M.
PUB. DATE
March 2009
SOURCE
Journal of Infectious Diseases;3/1/2009, Vol. 199 Issue 5, p737
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The dramatic antiviral activities of drugs that specifically inhibit hepatitis C virus replication can be tempered by baseline mutations that confer resistance. We describe the kinetics of an R155K mutation in hepatitis C virus (HCV) NS3 protease known to confer resistance to specific protease inhibitors in an individual coinfected with human immunodeficiency virus-1 and HCV. Longitudinal sequences revealed changes in the relative frequency with which this variant was observed independent of HCV replication levels, illustrating that this mutation coexists with wild-type strains in vivo in the absence of drugs. The persistence of drug-resistance mutations argues for baseline resistance genotyping at the time therapy is initiated to accurately predict the efficacy of treatment.
ACCESSION #
36666026

 

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