TITLE

IFN-γ Production during Active Tuberculosis Is Regulated by Mechanisms That Involve IL-17, SLAM, and CREB

AUTHOR(S)
Pasquinelli, Virginia; Townsend, James C.; Jurado, Javier O.; Alvarez, Ivana B.; Quiroga, María F.; Barnes, Peter F.; Samten, Buka; García, Verónica E.
PUB. DATE
March 2009
SOURCE
Journal of Infectious Diseases;3/1/2009, Vol. 199 Issue 5, p661
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis.
ACCESSION #
36666016

 

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