Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents

Rocha, Raquel; Cotrim, Helma Pinchemel; Vieira Bitencourt, Almir Galvão; Valente Barbosa, Daniel Batista; Santos, Adméia Souza; De Moura Almeida, Alessandro; Cunha, Bruno; Guimarães, Isabel
January 2009
World Journal of Gastroenterology;1/28/2009, Vol. 15 Issue 4, p473
Academic Journal
AIM: To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease (NAFLD) among asymptomatic Brazilian adolescents. METHODS: Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia, northeastern Brazil. The children answered a questionnaire that included age, gender, race, and medical history, and were submitted to a complete physical exam and abdominal ultrasound. Biochemical exams included: ALT, AST, GGT, C reactive protein (CRP), fasting glucose, insulin, cholesterol and triglycerides. Criteria for NAFLD included: the presence of steatosis in ultrasound and/or high level of ALT, negative or occasional historic of intake of alcohol (= 140 g/wk), negative investigation for hepatitis A, B, C, auto-immune hepatitis, Wilson disease and hemochromatosis. RESULTS: From October, 2005 to October, 2006, the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7 ± 2.0 years. One hundred ninety-nine had central obesity. The prevalence of NAFLD was 2.3%, most of whom were male and white. Insulin resistance (IR) was observed in 22.9% of them and had positive correlations with ALT and GGT ( P < 0.05). Elevated CRP was observed in 6.9% of the cases; however, it was not associated with WC, IR or liver enzymes. CONCLUSION: The prevalence of NAFLD in Brazilian adolescents was low. The ethnicity may have influence this frequency in the population studied, which had a large proportion of African descendents.


Related Articles

  • Esteatosis hepática, esteatohepatitis y marcadores de lesión hepática. Barba Evia, José Roberto // Revista Mexicana de Patologia Clinica;oct-dic2008, Vol. 55 Issue 4, p216 

    Nonalcohlic fatty liver disease affects a large proportion of the population. Is a clinicopathological entity characterized by the development of histological changes in the liver that are nearly identical to those induced by excessive alcohol intake, but in the absence of intake of this....

  • Leptin-to-adiponectin ratio in obese adolescents with nonalcoholic fatty liver disease. Angın, Yeliz; Arslan, Nur; Kuralay, Filiz // Turkish Journal of Pediatrics;May/Jun2014, Vol. 56 Issue 3, p259 

    The leptin-to-adiponectin (L/A) ratio has been used to show insulin resistance (IR) in recent years. The aim of this study was to investigate the L/A ratio in obese adolescents and compare this ratio in patients with and without nonalcoholic fatty liver disease (NAFLD) and also with healthy...

  • Alcoholic and Non-alcoholic Fatty Liver in Adolescents: A Worrisome Convergence. Nobili, Valerio; Pinzani, Massimo // Alcohol & Alcoholism;Sep/Oct2011, Vol. 46 Issue 5, p627 

    The article focuses on the relationship of liver damage with alcohol abuse and obesity. It states that the convergence of Non-alcoholic Fatty Liver Disease (NAFLD) and alcohol abuse is much relevance in adolescents. It says that binge drinking is the most common pattern in adolescents that leads...

  • Paediatric non-alcoholic fatty liver disease. Nobili, Valerio; Pinzani, Massimo // Gut;May2010, Vol. 59 Issue 5, p561 

    The article discusses the non-alcoholic fatty liver disease (NAFLD) in children. It mentions that NAFLD has become the common liver disease in children as well as adolescents due to overweight and obesity during their childhood. It states that NAFLD is associated with type 2 diabetes mellitus....

  • Models for Non-Alcoholic Fatty Liver Disease: A Link with Vascular Risk. Xirouchakis, E.; Sigalas, A.; Manousou, P.; Calvaruso, V.; Pleguezuelo, M.; Corbani, A.; Maimone, S.; Patch, D.; Burroughs, A. K. // Current Pharmaceutical Design;Feb2008, Vol. 14 Issue 4, p378 

    Non alcoholic fatty liver disease (NAFLD) is often part of the metabolic syndrome which includes central obesity, dyslipidaemia, insulin resistance/type 2 diabetes mellitus and hypertension. In turn, NAFLD may be associated with an increased vascular risk. Several experimental models which...

  • Role of -55CT polymorphism of UCP3 gene on non alcoholic fatty liver disease and insulin resistance in patients with obesity. Aller, R.; De Luis, D. A.; Izaola, O.; Sagrado, M. González; Conde, R.; Alvarez, T.; Pacheco, D.; Velasco, M. C. // Nutricion Hospitalaria;jul-ago2010, Vol. 25 Issue 4, p572 

    Background and aims: Some studies have pointed to a role of UCP3 in the regulation of biochemical and fat parameters in overweight patients. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene (rs1800849) on histological changes and insulin resistance in...

  • Hypoadiponectinemia and its Association with Liver Fibrosis in Morbidly Obese Patients. Nazal, Leyla; Riquelme, Arnoldo; Solís, Nancy; Pizarro, Margarita; Escalona, Alex; Burotto, Mauricio; Méndez, Juan; Saint-Jean, Catalina; Concha, Mariacute;a José; Giovanni, Stefano; Awruch, Diego; Morales, Arturo; Baudrand, Rene; Carrasco, Gonzalo; Domínguez, María Angélica; Padilla, Oslando; Espinoza, Manuel; Miquel, Juan Francisco; Nervi, Flavio; Arrese, Marco // Obesity Surgery;Oct2010, Vol. 20 Issue 10, p1400 

    Background: Reduced serum levels of adiponectin have been associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD). However, the relationship between serum adiponectin levels and hepatic histology in NAFLD is controversial. The aim of this study was to explore...

  • Surgical treatment of nonalcoholic fatty liver disease in severely obese patients. Vander Naalt, Steven J.; Gurria, Juan P.; Holterman, AiXuan L. // Hepatic Medicine: Evidence & Research;2014, Vol. 6, p103 

    Obesity is a multi-organ system disease with underlying metabolic abnormalities and chronic systemic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of obesity metabolic dysfunction and its associated cardiovascular- and liverrelated morbidities and mortality....

  • The impact of visceral fat in nonalcoholic fatty liver disease: cross-sectional and longitudinal studies. Koda, Masahiko; Kawakami, Manri; Murawaki, Yoshikazu; Senda, Miho // Journal of Gastroenterology;Nov2007, Vol. 42 Issue 11, p897 

    Nonalcoholic fatty liver disease is increasing worldwide, and attention is being paid to its association with obesity and metabolic syndrome. The aim of this study was to elucidate the role of visceral fat accumulation in hepatic steatosis by cross-sectional and longitudinal studies. We enrolled...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics