TITLE

Mycobacterium avium subspecies paratuberculosis and its relationship with Crohn's disease

AUTHOR(S)
Mendoza, Juan Luis; Lana, Raquel; Díaz-Rubio, Manuel
PUB. DATE
January 2009
SOURCE
World Journal of Gastroenterology;1/28/2009, Vol. 15 Issue 4, p417
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn's disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CD. Recently, genome-wide association studies have identified novel susceptibility genes for CD, which are critical for generation of an adaptive immune response that is protective against intracellular pathogens, including M. tuberculosis infection. However, the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients. Accordingly, this review sought neither to confirm nor refute this, but instead to survey recent literature on the role of MAP in CD.
ACCESSION #
36633597

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics