TITLE

Inability of healthy subjects to deposit potassium during hypokinesia and potassium supplementation

AUTHOR(S)
Zorbas, Yan G.; Kakuris, Kostas K.; Federenko, Yuri F.; Deogenov, Viktor A.
PUB. DATE
February 2009
SOURCE
Clinical & Investigative Medicine;Feb2009, Vol. 32 Issue 1, pE34
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To determine the effect of potassium (K+) supplementation and hypokinesia (HK; diminished movement) on muscle K+ content and K+ loss. Methods: Studies were conducted on 40 healthy male volunteers during a pre-experimental period of 30 days and an experimental-period of 364 days. Volunteers were equally divided into four groups: unsupplemented control subjects (UCS), unsupplemented experimental subjects (UES), supplemented control subjects (SCS), and supplemented experimental subjects (SES). A daily supplement of 1.17 mmol potassium-chloride (KCl) per kg body weight was given to the subjects in the SCS and SES groups. Results: Muscle K+ content decreased (P<0.05), and plasma K+ concentration, and K+ loss in urine and feces increased (P<0.05) in the SES and UES groups compared with their pre-experimental levels and the values in their respective control groups (SCS and UCS). Muscle K+ content decreased more (P<0.05), and plasma K+ concentration and K+ loss in urine and feces increased more (P<0.05) in the SES group than in the UES group. Conclusion: Muscle K+ content is not decreased by the K+ deficient diet and K+ loss is not increased by the higher muscle K+ content in the body. Rather it is caused by the inability of the body to use K+ during HK and K+ supplementation.
ACCESSION #
36620035

 

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