Efecto del Extracto de Pinus maritime, Vitaminas C y E, sobre la Concentración Sérica de LDLox, PCR, Selectina-E, IL-6 y Formación de Ateromas en Conejos con Dieta Hiperlipidémica

Figueira, Leticia; González, Julio C.
October 2008
Informe Medico;oct2008, Vol. 10 Issue 10, p34
Academic Journal
Antioxidants have been used to slow down or inhibit atherosclerosis. The objective of the present study was to compare the effect of pinus maritime, and of vitamins C and E, separately and combined, on serum concentration of oxLDL, E-selectin, IL-6, CRP and on the formation of aortic lesions in rabbits. 84 rabbits were studied: Group 1: commercial rabbit food (CRF) and vegetables. Group 2: Egg and (CRF). Group 3: Egg, (CRF) and Pinus maritime. Group 4: Egg, (CRF) and vitamin C. Group 5: Egg, (CRF) and vitamin E. Group 6: Egg, (CRF), Pinus maritime and vitamin C. Group 7: Egg, (CRF), Pinus maritime and vitamin E. The experiment lasted 12 weeks. Lipid profile, oxLDL, E-selectin, IL-6, vitamin E, vitamin C, PCR and histological study of rabbits' aorta were performed. Antioxidant supplement decreased oxLDL, E-selectine, IL-6 (p<0,05) and inhibited aortic lesions. In conclusion, antioxidants were effective in slowing down inflammation and oxidation markers, and the formation and progression of atheroma.


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