In Vitro Metabolism of 4-Androstene-3,17-Dione by Human Submaxillary Gland Homogenates

March 1977
Journal of Dental Research;Mar1977, Vol. 56 Issue 3, p332
Academic Journal
Tritiated 4-androstene-3,17-dione was incubated with human submaxillary gland homogenates. In 180-minute incubations, human submaxillary gland converted 4-androstene-3,17-dione predominately to testosterone and to a lesser extent, 5α-androstane-3α,17β-diol and androsterone.


Related Articles

  • In vitro Metabolism of 4-androstene-3,17-dione by Rhesus Monkey Submandibular Gland Homogenates. COFFEY, J. C.; JOHNSONBAUGH, R. E. // Journal of Dental Research;Mar1981, Vol. 60 Issue 3, p727 

    This article discusses the results of a research study conducted to determine the capability of the submandibular gland (SMG) of rhesus monkeys to metabolize androgens, specifically 4-androstene-3, 17-dione. The study concludes that the SMG of the adult monkey reductively metabolizes androgens,...

  • In vitro Androgen Metabolism in Submandibular Glands of Normal and Diabetic (C57BL/KsJ db/db) Mice. COFFEY, JAMES C.; CARSON, KEITH A.; HANKER, JACOB S. // Journal of Dental Research;Apr1981, Vol. 60 Issue 4, p830 

    This article discusses the results of a research study conducted to determine the androgen metabolizing capability of the submandibular glands (SMG) of normal and diabetic male and female mice. The study concludes that an observed masculinization of the female diabetic SMG and feminization of...

  • Metabolism of Androgens by Human Periodontal Ligament. VITTEK, J.; RAPPAPORT, S. C.; GORDON, G. G.; HAGEDOORN, J.; SOUTHREN, A. L. // Journal of Dental Research;Oct1982, Vol. 61 Issue 10, p1153 

    The metabolism of androgens (testosterone and androstenedione) has been studied in healthy and diseased human periodontal ligaments. An increased activity of 17β-oxidoreductase and 17-keto-5α-A-ring reductase and decreased activity of 17β-hydroxy-5α-A-ring reductase,...

  • Cortisol and testosterone increase financial risk taking and may destabilize markets. Cueva, Carlos; Roberts, R. Edward; Spencer, Tom; Rani, Nisha; Tempest, Michelle; Tobler, Philippe N.; Herbert, Joe; Rustichini, Aldo // Scientific Reports;7/3/2015, p11206 

    It is widely known that financial markets can become dangerously unstable, yet it is unclear why. Recent research has highlighted the possibility that endogenous hormones, in particular testosterone and cortisol, may critically influence traders' financial decision making. Here we show that...

  • Yolk androstenedione, but not testosterone, predicts offspring fate and reflects parental quality. Hegyi, Gergely; Herényi, Márton; Szöllősi, Eszter; Rosivall, Balázs; Török, János; Groothuis, Ton G. G. // Behavioral Ecology;Jan2011, Vol. 22 Issue 1, p29 

    Yolk androgen deposition is a widely investigated maternal effect in birds, but its adaptive value is at present unclear. The offspring fitness correlates of natural yolk androgen levels are virtually unknown, whereas manipulations largely focused on testosterone and neglected other androgens....

  • Effects of Androgens on the Activity of Steroid-metabolizing Enzymes in the Murine Submaxillary Gland. KATSUKAWA, H.; TANABE, Y.; FUNAKOSHI, M. // Journal of Dental Research;Jun1983, Vol. 62 Issue 6, p725 

    Effects of androgens on the activity of androgen-metabolizing enzymes have been investigated in the murine submaxillary gland. 5α-reductase activity is androgen-dependent, and 17β-hydroxysteroid dehydrogenase activity is androgen-resistant. The level and androgen-responsiveness of...

  • Levels of Dihydrotestosterone, Testosterone, Androstenedione, and Estradiol in Canalicular, Saccular, and Alveolar Mouse Lungs. Boucher, Eric; Provost, Pierre R.; Devillers, Audrey; Tremblay, Yves // Lung;Jun2010, Vol. 188 Issue 3, p229 

    Androgens and estrogens are known regulators of fetal and postnatal lung development, but their levels in the developing lung have never been determined. We present here, for the first time, a gas chromatography-mass spectrometry (GC/MS) quantification of dihydrotestosterone, testosterone,...

  • Development of Responsiveness of Mouse Submandibular Gland to Androgen and Thyroid Hormone. TAKUMA, TAISHIN; HOSODA, SATOKO; TANEMURA, TATSUYA; KUMEGAWA, MASAYOSHI // Journal of Dental Research;Jan1981, Vol. 60 Issue 1, p77 

    The effects of thyroxine and 5α-dihydrotestosterone on the activities of various marker enzymes in the submandibular glands of immature mice were studied. The responsiveness to thyroid hormone appeared at latest by day five after birth, which was ten d earlier than the appearance of androgen...

  • Hormonal Influence on Rat Submandibular-Gland Histochemistry. KRONMAN, JOSEPH H.; CHAUNCEY, HOWARD H. // Journal of Dental Research;Jul1964, Vol. 43 Issue 4, p520 

    The article looks at a study which examined the hormonal influences of the histochemistry of the submandibular gland in albino rats. The effects of testosterone and thyroxine on normal and hypophysectomized rats are focused on. The author notes that atrophic changes made to the submandibular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics