Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas

Kircher, Tilo; Thienel, Renate; Wagner, Michael; Reske, Martina; Habel, Ute; Kellermann, Thilo; Frommann, Ingo; Schwab, Sibylle; W�lwer, Wolfgang; von Wilmsdorf, Martina; Braus, Dieter F.; Schmitt, Andrea; Rapp, Alexander; St�cker, Tony; Shah, N. Jon; Henn, Fritz A.; Sauer, Heinrich; Gaebel, Wolfgang; Maier, Wolfgang; Schneider, Frank
March 2009
European Archives of Psychiatry & Clinical Neuroscience;Mar2009, Vol. 259 Issue 2, p72
Academic Journal
The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations ( P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation.


Related Articles

  • Neural correlates of executive function and working memory in the 'at-risk mental state'. Broome, Matthew R.; Matthiasson, Pall; Fusar-Poli, Paolo; Woolley, James B.; Johns, Louise C.; Tabraham, Paul; Bramon, Elvira; Valmaggia, Lucia; Williams, Steven C. R.; Brammer, Michael J.; Chitnis, Xavier; McGuire, Philip K. // British Journal of Psychiatry;Jan2009, Vol. 194 Issue 1, p25 

    Background: People with prodromal symptoms have a very high risk of developing psychosis.Aims: To use functional magnetic resonance imaging to examine the neurocognitive basis of this vulnerability.Method: Cross-sectional comparison of regional activation...

  • Nicotine improves delayed recognition in schizophrenic patients. Myers, Carol S.; Robles, Olalla; Kakoyannis, A. Nancy; Sherr, Jay D.; Avila, Matthew T.; Blaxton, Teresa A.; Thaker, Gunvant K. // Psychopharmacology;2004, Vol. 174 Issue 3, p334 

    Rationale. Nicotine has been shown to enhance some aspects of memory, attention and cognition in normal subjects and in some patient populations such as Alzheimer’s and Parkinson’s disease groups. Objectives. Memory disorders are consistently observed in schizophrenic patients, so...

  • Schizophrenia and Related Disorders.  // Current Medical Literature: Psychiatry;2006, Vol. 17 Issue 4, p122 

    The article reflects on studies about schizophrenia and related disorders. It explains the Theory of Mind deficits in schizophrenia patients. It recommends further research on the working memory process in schizophrenia. It points out the value of a study that analyzed the structure of the...

  • Contribution of Working Memory Components to the Performance of the Tower of Hanoi in Schizophrenia. Chan, R. C. K.; Wang, Y. N.; Cao, X. Y.; Chen, E. Y. H. // East Asian Archives of Psychiatry;Jun2010, Vol. 20 Issue 2, p69 

    Objectives: To examine the underlying structure of neuropsychological tests involving working memory components and those not involving working memory components that contribute to the performance of the Tower of Hanoi task in schizophrenic patients. Participants and Methods: A total of 90...

  • Polymorphism of Serotonin Receptor Genes (5-HTR2A) and Dysbindin (DTNBP1) and Individual Components of Short-Term Verbal Memory Processes in Schizophrenia. Alfimova, M. V.; Monakhov, M. V.; Abramova, L. I.; Golubev, S. A.; Golimbet, V. E. // Neuroscience & Behavioral Physiology;Oct2010, Vol. 40 Issue 8, p934 

    ociations between polymorphisms in the T102C and A-1438G loci of the 5-HTR2A and the P1763 and P1578 markers of the DTNBP1 gene with the overall productivity and individual subprocesses of shortterm verbal memory were studied in 4–5 patients with schizophrenia and 290 healthy subjects....

  • Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling. Barnett, Jennifer H.; Croudace, Tim J.; Jaycock, Sue; Blackwell, Candice; Hynes, Fiona; Sahakian, Barbara J.; Joyce, Eileen M.; Jones, Peter B. // BMC Psychiatry;2007, Vol. 7, p16 

    Background: Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function. Methods: This longitudinal study aimed to establish whether there was stability, improvement or decline in memory...

  • P300 amplitude is insensitive to working memory load in schizophrenia. Gaspar, Pablo A.; Ruiz, Sergio; Zamorano, Francisco; Altayó, Marcela; Pérez, Carolina; Bosman, Conrado A.; Aboitiz, Francisco // BMC Psychiatry;2011, Vol. 11 Issue 1, p29 

    Background: Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to have an aberrant brain connectivity and impairments in WM capacity. The...

  • Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.  // Current Medical Literature: Psychiatry;2004, Vol. 15 Issue 2, p45 

    Discusses research being done on the function of the dorsolateral prefrontal cortex in schizophrenia. Reference to a study by J. H. Callicott, V. S. Mattay, B. A. Verchinski, S. Marenco and M. F. Egan, published in the 2003 issue of the "American Journal of Psychiatry"; Methodology used;...

  • Enhanced top-down control during pursuit eye tracking in schizophrenia. Sprenger, Andreas; Trillenberg, Peter; Nagel, Matthias; Sweeney, John; Lencer, Rebekka // European Archives of Psychiatry & Clinical Neuroscience;Apr2013, Vol. 263 Issue 3, p223 

    Alterations in sensorimotor processing and predictive mechanisms have both been proposed as the primary cause of eye tracking deficits in schizophrenia. 20 schizophrenia patients and 20 healthy controls were assessed on blocks of predictably moving visual targets at constant speeds of 10, 15 or...


Read the Article

Other Topics