TITLE

Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas

AUTHOR(S)
Kircher, Tilo; Thienel, Renate; Wagner, Michael; Reske, Martina; Habel, Ute; Kellermann, Thilo; Frommann, Ingo; Schwab, Sibylle; W�lwer, Wolfgang; von Wilmsdorf, Martina; Braus, Dieter F.; Schmitt, Andrea; Rapp, Alexander; St�cker, Tony; Shah, N. Jon; Henn, Fritz A.; Sauer, Heinrich; Gaebel, Wolfgang; Maier, Wolfgang; Schneider, Frank
PUB. DATE
March 2009
SOURCE
European Archives of Psychiatry & Clinical Neuroscience;Mar2009, Vol. 259 Issue 2, p72
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations ( P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation.
ACCESSION #
36548811

 

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