TITLE

Characterization of Low-molecular-weight Peptides in Human Parotid Saliva

AUTHOR(S)
Perinpanayagam, H. E. R.; VanWuyckhuyse, B. C.; Ji, Z. S.; Tabak, L. A.
PUB. DATE
January 1995
SOURCE
Journal of Dental Research;Jan1995, Vol. 74 Issue 1, p345
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The low-molecular-weight components of human saliva remain poorly characterized. Therefore, low- molecular-weight peptides (Mr < 3000) have been purified from human parotid saliva and characterized with respect to their amino acid sequence. From the sequences obtained, it is likely that these peptides are derived from proteolysis of the hydroxyapatite-interactive human salivary proteins, histatins, proline-rich proteins, and statherins. Since human parotid saliva is an amicrobial fluid, much of the low-molecular-weight peptide fraction of this secretion appears to be derived from the proteolytic processing of the larger proteins. Because of their small size, these peptides are likely to be in exchange with dental plaque fluid and may therefore help modulate events such as demineralization/remineralization, microbial attachment, and dental plaque metabolism at the tooth-saliva interface.
ACCESSION #
36529043

 

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